摘要
采用中红外(MIR)光谱(包括:一维中红外(MIR)光谱、二阶导数中红外(MIR)光谱、四阶导数中红外(MIR)光谱及去卷积中红外(MIR)光谱)开展了物理阻隔剂结构的研究。实验发现:物理阻隔剂的红外吸收模式主要包括:νasCH_(3)-物理阻隔剂、νsCH_(3)-物理阻隔剂、νasCH_(2)-物理阻隔剂、νsCH_(2)-物理阻隔剂、δasCH_(3)-物理阻隔剂、δsCH_(3)-物理阻隔剂、δCH_(2)-物理阻隔剂和ρCH_(2)-物理阻隔剂。物理阻隔剂主要化学结构为长碳链烷烃。拓展了MIR光谱在重要的治疗过敏性鼻炎药物(物理阻隔剂)分子结构的研究范围。
The physical blocker structure had been studied by middle infrared(MIR)spectroscopy(including:one-dimensional middle infrared(MIR)spectroscopy,second derivative middle infrared(MIR)spectroscopy,fourth derivative middle infrared(MIR)spectroscopy and deconvolution middle infrared(MIR)spectroscopy).The infrared absorption modes of physical blocker includedνasCH_(3)-physical blocker,νsCH_(3)-physical blocker,νasCH_(2)-physical blocker,νsCH_(2)-physical blocker,δasCH_(3)-physical blocker,δsCH_(3)-physical blocker,δCH_(2)-physical blocker andρCH_(2)-physical blocker.It was found the physical blocker structure was long carbon chain alkane.The key roles of MIR spectroscopy in the analysis of molecular structure of the important drugs for treating allergic rhinitis(physical blocker)were demonstrated.
作者
戎媛
张雨萱
张蕊
李佳欣
孟露
杜龙伟
常明
徐元媛
Rong Yuan;Zhang Yuxuan;Zhang Rui;Li Jiaxin;Meng Lu;Du Longwei;Chang Ming;Xu Yuanyuan(Shijiazhuang University,School of Chemical Engineering,Shijiazhuang 050035,China)
出处
《煤炭与化工》
CAS
2022年第10期133-138,143,共7页
Coal and Chemical Industry
基金
2022年度河北省大中学生科技创新能力培育专项(22E502380)
石家庄学院博士科研启动基金(20BS008)。
关键词
物理阻隔剂
中红外光谱
结构
鼻炎
physical blocker
MIR spectroscopy
structure
allergic rhinitis
