摘要
创伤后脑梗死(post-traumatic cerebral infarction,PTCI)是创伤性颅脑损伤(traumatic brain injury,TBI)后严重继发性损伤之一,常直接导致高死亡率和残疾率,严重影响患者的生存及预后情况。其发病机制至今仍在探讨中,早期识别存在PTCI风险将有助于该类患者的管理,对预防PTCI发生具有重要意义。本文通过总结目前已发表文章中PTCI相关机制及危险因素,发现机械压迫、凝血功能障碍、血管痉挛可能是其形成的重要机制,相关危险因素包括去骨瓣减压术、较低的入院格拉斯哥昏迷评分、蛛网膜下腔出血、低血压、弥漫性血管内凝血、颅内占位。
Post-traumatic cerebral infarction(PTCI)is one of the common severe secondary injuries after traumatic brain injury,which often leads to high mortality and disability rate directly,and severely affects the survival and prognosis of patients.The mechanisms of PTCI pathogenesis is still being explored.Early identification of patients with PTCI risk will help the management of patients and is of great significance for preventing the occurrence of PTCI.This article summarizes the relevant mechanisms and risk factors of PTCI in published articles.Mechanical compression,coagulation disorders,and vasospasm have been found to be potentially important mechanisms for its formation,as well as associated risk factors including debridement decompression,lower admission Glasgow coma score,subarachnoid hemorrhage,hypotension,diffuse intravascular coagulation,and intracranial occupancy.
作者
崔俊杰
孙建军
李贺
荔志云
CUI Jun-jie;SUN Jianjun;LI He;LI Zhiyun(Department of Neurosurgery,Gansu Central Hospital,No.999 Mogao Avenue,Anning District,Lanzhou,Gansu 730046,China)
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2022年第8期498-502,共5页
Chinese Journal of Nervous and Mental Diseases
基金
甘肃省重点研发专项计划(编号:17YF1FA136)。
关键词
创伤后脑梗死
创伤性颅脑损伤
机制
危险因素
研究进展
凝血功能障碍
血管痉挛
蛛网膜下腔出血
Post-traumatic cerebral infarction
Traumatic brain injury
Mechanism
Risk factors
Research progress
Coagulation disorder
Vasospasm
Subarachnoid hemorrhage
