摘要
目的 探究老年肺癌患者术后血和肽素、胰岛素样生长因子-1(IGF-1)、Ⅳ型胶原(Ⅳ-C)水平与其并发肺部感染及感染转归关系。方法 选取2019年3月-2021年3月医院120例老年肺癌患者作为研究对象,根据术后是否发生肺部感染分为感染组25例、非感染组95例,检测两组术后第1、3、5、7天和肽素、IGF-I、Ⅳ-C水平。结果 术后第3、5、7天,感染组和肽素、IGF-I、Ⅳ-C水平均高于非感染组(P<0.05);老年肺癌并发肺部感染患者术后第5天CPIS评分为(7.78±0.65)分,与和肽素、IGF-I、Ⅳ-C水平呈正相关关系(P<0.05);绘制ROC曲线显示,术后第5天和肽素、IGF-I、Ⅳ-C水平联合诊断老年肺癌患者术后并发肺部感染AUC最大,>0.9,具有良好诊断效能;随访6个月,术后第5天和肽素、IGF-I、Ⅳ-C水平联合诊断阳性患者死亡率高于阴性患者(P<0.05)。结论 老年肺癌并发肺部感染患者和肽素、IGF-I、Ⅳ-C水平明显升高,三种指标与患者感染程度及转归具有一定相关性,临床监测其水平,有助于早期感染控制,改善患者预后。
OBJECTIVE To investigate the relationship between postoperative blood and peptide, insulin-like growth factor-1(IGF-1) and type IV collagen(IV-C) levels and their concurrent pulmonary infections and infection outcome in elderly lung cancer patients. METHODS A total of 120 elderly patients with lung cancer in our hospital from Mar 2019 to Mar 2021 were recruited and divided into the infection group(25 cases) and non-infection group(95 cases) according to whether pulmonary infection occurred after operation. IGF-I and IV-C levels in both groups were detected on postoperative day 1, 3, 5 and 7. RESULTS On postoperative days 3, 5 and 7, the levels of hepcidin, IGF-I and IV-C were significantly higher in the infected group than those in the non-infected group(P<0.05);the CPIS score on postoperative day 5 in elderly patients with lung cancer complicated with lung infection was(7.78±0.65), which was positively correlated with the levels of hepcidin, IGF-I and IV-C(P<0.05);ROC curve showed that the AUC of the combined detection of hepcidin, IGF-I and IV-C on postoperative day 5 was the largest, >0.9, which showed good diagnostic efficacy. The mortality rate of patients with positive combined diagnosis of peptide, IGF-I, and IV-C levels on postoperative day 5 were significantly higher than that of negative patients after 6-month follow-up(P<0.05). CONCLUSION The levels of copeptin, IGF-I, and IV-C in elderly patients with lung cancer complicated by pulmonary infection significantly increased. The three indicators have a certain correlation with the degree of infection and outcome of the patients. Clinical monitoring of the above indexes can help early infection control and improve the prognosis of patients.
作者
朱秀英
朱林文
张旭红
李旎
施丽红
ZHU Xiu-ying;ZHU Lin-wen;ZHANG Xu-hong;LI Ni;SHI Li-hong(Li Huili Hospital,Ningbo Medical Center,Ningbo,Zhejiang 315040,China;不详)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2022年第16期2487-2490,共4页
Chinese Journal of Nosocomiology
基金
宁波市自然科学基金资助项目(202003N4269)。
关键词
肺癌
老年
肺部感染
和肽素
胰岛素样生长因子-1
Ⅳ型胶原
感染转归
Lung cancer
Elderly
Lung infection
Peptide
Insulin-like growth factor-1
Type IV collagen
Infection regression
