摘要
肌细胞特异性microRNAs(MyomiRs)是一类肌肉细胞特异性的微小RNA,仅在肌肉中表达,能够调节细胞功能的多个方面,包括生长、分化、代谢、免疫、细胞死亡、信号信使、DNA修复和自我更新等,参与炎症、免疫、肿瘤等疾病的病理过程,主要包含有7个子集:miR-1、miR-133a、miR-133b、miR-206、miR-208a、miR-208b、miR-499。由于其在多种疾病中表达的差异性,可将其用于筛选、识别、分类、监测或预测疾病的风险程度和治疗效果,可作为多种疾病的生理、病理过程的标志物,如肌肉减少症等肌肉相关性疾病,高血压、心肌梗死等心血管疾病,慢性阻塞性肺疾病、支气管哮喘等呼吸系统疾病,食管癌、胰腺癌等恶病质疾病以及糖尿病、类风湿性关节炎等。本综述的目的是总结MyomiRs作为生物学标志在多种疾病中的研究现状,为临床的诊断、治疗和判断预后提供参考。
Muscle-specific microRNAs(MyomiRs)are a class of muscle cell-specific microRNAs that are expressed only in muscle and are capable of regulating multiple aspects of cellular function,including growth,differentiation,metabolism,immunity,cell death,signaling messengers,DNA repair and self-renewal,etc.They are involved in the pathological processes of inflammation,immunity,tumors and other diseases,mainly including 7 subsets:miR-1,miR-133a,miR-133b,miR-206,miR-208a,miR-208b,miR-499.Due to the differences in its expression in various diseases,it can be used to screen,identify,classify,monitor or predict the degree of risk and treatment effect of diseases,and can be used as markers of physiological and pathological processes of various diseases.For example,muscle related diseases such as hypoxia,cardiovascular diseases such as hypertension and myocardial infarction,respiratory diseases such as chronic obstructive pulmonary disease and bronchial asthma,cachexia diseases such as esophageal cancer and pancreatic cancer,and other diseases such as diabetes and rheumatoid arthritis related diseases.The purpose of this review is to summarize the research status of MyomiRs as biological markers in various diseases,and to provide reference for clinical diagnosis,treatment and prognosis.
作者
李小珍
李大治
王春娥
魏萍
LI Xiaozhen;LI Dazhi;WANG Chun′e;WEI Ping(The Second Clinical Medical College,Fujian University of Traditional Chinese Medicine,Fujian Province,Fuzhou 350122,China;Department of Respiratory,the Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Fujian Province,Fuzhou 350003,China)
出处
《中国当代医药》
CAS
2022年第31期36-40,共5页
China Modern Medicine
基金
国家自然科学基金资助项目(81973820)。
