摘要
目的:研究间歇性θ短阵脉冲经颅磁刺激联合动作观察疗法对轻、中度阿尔茨海默病患者认知功能的影响。方法:选取轻、中度阿尔茨海默病患者52例随机分为观察组和对照组各26例。2组患者均接受常规药物治疗、认知功能训练、运动训练。对照组在此基础上采用动作观察疗法,观察组在对照组基础上联合间歇性θ短阵脉冲经颅磁刺激治疗。2组疗程均为4周。采用蒙特利尔认知评估(MoCA)、简易智能精神状态检查量表(MMSE)进行认知功能评估;采用改良Barthel指数、功能活动问卷FAQ进行日常生活活动能力的评估。结果:2组治疗后MMSE评分、MoCA评分均高于治疗前,观察组MMSE评分、MoCA评分改善幅度均高于对照组,差异有统计学意义(P<0.05)。2组治疗后FAQ评分高于治疗前(P<0.05),观察组Barthel指数评分与FAQ评分改善幅度均高于对照组,差异有统计学意义(P<0.05)。结论:间歇性θ短阵脉冲经颅磁刺激联合动作观察疗法可以改善轻、中度阿尔茨海默病患者的认知功能,提高患者的日常生活活动能力,有望在临床上推广使用。
Objective:To study the effect of intermittentθshort pulse stimulation(iTBS)combined with action observation therapy on cognitive function of patients with Alzheimer’s disease(AD).Methods:In this controlled trial,52 patients with mild and moderate AD were selected,and randomly divided into control group(n=26)and observation group(n=26)according to the random number table method.Both groups received conventional drug therapy,cognitive function training and exercise training.The observation group received iTBS combined with action observation therapy(AOT),and the control group only received AOT.The treatment course of both groups was 4 weeks.Monterial cognitive assessment(MoCA)and Simple Mental State Inventory(MMSE)were used to assess cognitive function.The modified Barthel index and functional activity questionnaire(FAQ)were used to evaluate the daily living activities.Results:MMSE score and MoCA score after treatment in the two groups were higher than those before treatment,and the improvement of MMSE score and MoCA score in the observation group was better than that in the control group with the difference being statistically significant(P<0.05).Barthel index score and FAQ score in both groups were higher after treatment than before treatment,and the improvement of Barthel index score and FAQ score in the observation group was higher than that in the control group with statistically significant difference(P<0.05).Conclusion:iTBS combined with action observation therapy can improve the function of mild-to-moderate AD patients and improve their ability of daily living activities,which is worthy of clinical application.
作者
蒋孝翠
苏清伦
赵秦
刘臻
贾旭武
Jiang Xiaocui;Su Qinglun;Zhao Qin(The First Affiliated Hospital of Kangda College of Nanjing Medical University(The First People’s Hospital of Lianyungang),Lianyungang 222000,China)
出处
《中国康复》
2022年第11期660-664,共5页
Chinese Journal of Rehabilitation
关键词
阿尔茨海默病
θ短阵脉冲刺激
动作观察疗法
认知
Alzheimer’s disease
theta burst stimulation
action observation therapy
cognitive function
