摘要
目的探讨还原型谷胱甘肽联合复方甘草酸苷治疗急性药物性肝病的效果。方法抽取2019年6月至2021年6月开封市传染病医院收治的78例急性药物性肝病患者,采用双色球法分为对照组与观察组,每组39例。对照组采用还原型谷胱甘肽治疗,观察组采用还原型谷胱甘肽联合复方甘草酸苷治疗。比较两组的治疗效果,治疗前后肝功能指标[血清总胆红素(TBiL)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)]、血清炎性因子[C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)]水平,不良反应发生情况。结果观察组总有效率(92.31%,36/39)高于对照组(71.79%,28/39),P<0.05。治疗前,两组肝功能指标及血清炎性因子水平比较差异未见统计学意义(P>0.05);治疗后,观察组TBiL、ALT、AST及CRP、PCT、IL-6水平均低于对照组(P均<0.05)。两组不良反应发生率比较差异未见统计学意义(P>0.05)。结论急性药物性肝病采取还原型谷胱甘肽与复方甘草酸苷联合治疗,可提高疗效,更好地改善肝功能指标,促进炎性因子水平下降,且不增加不良反应。
Objective To investigate the curative effect of reduced glutathione combined with compound glycyrrhizin on acute drug-induced liver disease.Methods A total of 78 patients with acute drug-induced liver disease treated in Kaifeng Infectious Disease Hospital from June 2019 to June 2021 were selected.They were divided into control group and observation group by double color ball method,with 39 cases in each group.The control group was treated with reduced glutathione,while the observation group was treated with reduced glutathione combined with compound glycyrrhizin.The therapeutic effects of the two groups were compared.The preoperative and postoperative liver function indexes including serum total bilirubin(TBIL),alanine aminotransferase(ALT),aspartate aminotransferase(AST)and serum inflammatory factors including C-reactive protein(CRP),procalcitonin(PCT)and interleukin-6(IL-6),and incidence of adverse reactions were compared between the two groups.Results Compared with the control group,The total effective rate of the observation group(92.31%,36/39)was higher than that of the control group(71.79%,28/39),P<0.05.Before treatment,there was no significant difference in liver function indexes and levels of serum inflammatory factors between the groups(P>0.05).After treatment,the levels of serum TBiL,ALT,AST,CRP,PCT and IL-6 in the observation group were lower than those of the control group(all P<0.05).There was no significant difference in incidence of adverse reactions between the two groups(P>0.05).Conclusions Reduced glutathione combined with compound glycyrrhizin in the treatment of acute drug-induced liver disease can improve the curative effect,improve liver function indexes,and promote the decrease of inflammatory factor levels,but does not significantly increase adverse reactions.
作者
赫琰
王景春
He Yan;Wang Jingchun(Department of Pharmacy and Equipment,Kaifeng Infectious Disease Hospital,Kaifeng 475001,China;Department of Pharmacy,the First Affiliated Hospital of Henan University,Kaifeng 475001,China)
出处
《中国实用医刊》
2022年第16期94-97,共4页
Chinese Journal of Practical Medicine
关键词
急性药物性肝病
还原型谷胱甘肽
复方甘草酸苷
肝功能指标
炎性因子
生活质量
Acute drug-induced liver disease
Reduced glutathione
Compound glycyrrhizin
Liver function indexes
Inflammatory factors
Quality of life
