摘要
为了增加电化学方法中微流控芯片内抗原抗体结合效果,提高生物病毒检测效率,这里对微流控芯片中的I型微流道内流场状态进行数值模拟,确定了微流控芯片中金箔电极设计的最优方案。这里通过对微流道流体的速度、雷诺数及壁面压力进行数值模拟试验,试验结果表明在微流道入口后三分之一处为金箔电极敷设的最佳区域,并根据数值模拟试验结果,设计了面向生物安全检测的微流控芯片。研究结果对于提高生物快检技术的检测效率有着较好的实际意义。
In order to increase the binding effect of antigen and antibody in microfluidic chip,and also to improve the detection efficiency of biological virus,the numerical simulation of type I microchannel flow field in the microfluidic chip is carried out,and the optimal design scheme of gold foil electrode in microfluidic chip is determined.The flow velocity,Reynolds number and wall pressure in the microchannel are simulated,and the results show that the best area for laying gold foil electrode is the third of the microchannel inlet.According to the numerical simulation experiments,a microfluidic chip for biosecurity detection is designed,and the results of this paper have a good practical significance for improving the detection efficiency of biological rapid detection technology.
作者
善盈盈
李琛
郭黎明
SHAN Ying-ying;LI Chen;GUO Li-ming(School of Mechanical Engineering,Zhejiang Institute of Mechanical&Electrical Engineering,Zhejiang Hangzhou 310053,China;College of Quality and Safety Engineering,China Jilang University,Zhejiang Hangzhou 310018,China)
出处
《机械设计与制造》
北大核心
2022年第11期94-97,共4页
Machinery Design & Manufacture
基金
浙江省基础公益研究计划(GF19F010012)
国家重点研发计划(2018YFC0809200)。
关键词
生物安全
电化学
微流控
雷诺数
Biological Safety
Electrochemistry
Microfluidics
Reynolds Number
