摘要
目的探讨腹腔镜辅助下胃癌根治术治疗老年胃癌患者的安全性及对疼痛因子的影响。方法将65例老年胃癌患者按照手术方式的不同分为观察组(n=34)和对照组(n=31),对照组患者采用开腹手术治疗,观察组患者采用腹腔镜辅助下胃癌根治术治疗,比较两组患者围手术期指标、氧化应激指标、疼痛因子及并发症发生情况。结果观察组患者术中出血量明显少于对照组,胃肠功能恢复时间和住院时间均明显短于对照组,差异均有统计学意义(P﹤0.01)。术后,两组患者超氧化物歧化酶(SOD)水平均低于本组术前,丙二醛(MDA)水平均高于本组术前,但观察组患者SOD水平高于对照组,MDA水平低于对照组,差异均有统计学意义(P﹤0.05)。术后,两组患者前列腺素E_(2)(PGE_(2))、P物质(SP)水平均高于本组术前,但观察组患者PGE_(2)、SP水平均低于对照组,差异均有统计学意义(P﹤0.05)。两组患者并发症总发生率比较,差异无统计学意义(P﹥0.05)。结论腹腔镜辅助下胃癌根治术可减少老年胃癌患者术中出血量,改善机体氧化应激反应和术后疼痛程度,加快术后恢复,且不增加并发症的发生风险。
Objective To investigate the safety of laparoscopic-assisted radical gastrectomy for elderly patients with gastric cancer and its impact on pain factors.Method A total of 65 elderly gastric cancer patients were divided into ob-servation group(n=34)and control group(n=31)according to different surgical methods.The patients in the control group were treated with open surgery,while the patients in the observation group were treated with laparoscopic-assisted radical gastrectomy.The perioperative indicators,oxidative stress indicators,pain factors,and complications were com-pared between the two groups.Result The intraoperative blood loss volume in the observation group was significantly less than that in the control group,and the recovery time of the gastrointestinal function and hospital stay were significant-ly shorter than those in the control group,and the differences were statistically significant(P<0.01).After the operation,the levels of superoxide dismutase(SOD)in both groups were lower than those before surgery,and the levels of malonic dialdehyde(MDA)were higher than those before surgery,and the SOD level in the observation group was higher than that in the control group,the MDA level was lower than that in the control group,and the differences were statistically sig-nificant(P<0.05).After the operation,the levels of prostaglandin E_(2)(PGE_(2))and substance P(SP)in the two groups were higher than those before the operation,while the levels of PGE_(2) and SP in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the to-tal incidence of complications between the two groups(P>0.05).Conclusion Laparoscopic-assisted radical gastrectomy can reduce intraoperative bleeding,improve the body's oxidative stress response and postoperative pain,and speed up postoperative recovery without increasing the risk of complications.
作者
李广城
曹冬
LI Guangcheng;CAO Dong(Second Department of General Surgery,People's Hospital of Ruichang City,Ruichang 32200,Jiangxi,China)
出处
《癌症进展》
2022年第19期1977-1979,1982,共4页
Oncology Progress
关键词
胃癌
腹腔镜辅助下胃癌根治术
开腹手术
安全性
疼痛因子
gastric cancer
laparoscopic-assisted radical gastrectomy
open surgery
safety
pain factor
