摘要
癌症生物标志物作为一种特定的身体中可测量的指标,可以通过自身产生的变化来监测癌症健康状况,对于癌症的预防、早期诊断和精准治疗具有重要意义。因此,面向典型疾病标志物的快速检测与精准分析已成为科学研究和临床诊断的热点领域。基于分子印迹的生物传感器由于其灵敏度高、响应速度快、特异性强以及成本低等优点,有望成为癌症生物标志物快速检测的新手段,在癌症临床分析领域得到了广泛研究。本综述简要介绍了分子印迹聚合物的合成方法和策略,分子印迹与电化学、表面等离子共振和光学分析集成的传感技术和手段,以及分子印迹生物传感在癌症生物标志物的应用。最后本综述就目前国内外关于分子印迹传感器在分析检测癌症生物标志物领域的应用现状进行了总结和讨论,并展望了其未来发展前景。
Cancer biomarkers,as specific measurable indicators in the body,can monitor cancer health through their own changes,and are of great significance for cancer prevention,early diagnosis and precise treatment.Therefore,rapid detection and precise analysis of typical disease markers have become a hot field of scientific research and clinical diagnosis.Molecular imprinting-based bio-sensing technology is expected to become a new method for rapid detection of disease markers due to its high sensitivity,fast response,strong specificity and low cost,and has been widely studied in the field of cancer clinical analysis.This review introduces the molecularly imprinted polymer synthetic methods and strategies,the sensor technology and means through the combination of molecular imprinting with electrochemical,surface plasma resonance and optical analysis,and the application of molecularly imprinted sensor in prostate cancer,breast cancer,liver cancer and other cancers biomarkers.Finally,this review summarizes the application status of molecularly imprinted sensors in the analysis and detection of cancer biomarkers at home and abroad,and puts forward the prospect of its development in the future.
作者
罗爱芹
蔡艳慧
梁阿新
解炳腾
LUO Aiqin;CAI Yanhui;LIANG Axin;XIE Bingteng(Key Laboratory of Molecular Medicine and Biotherapy,the Ministry of Industry and Information Technology,School of Life Science,Beijing Institute of Technology,Beijing 100081,China)
出处
《化工进展》
EI
CAS
CSCD
北大核心
2022年第S01期448-460,共13页
Chemical Industry and Engineering Progress
基金
国家重点研发计划(2019YFA0904104)。
关键词
分子印迹
电化学
生物传感
癌症生物标志物
早期诊断
检测
molecular imprinting
electrochemistry
bio-sensing
cancer biomarker
early diagnosis
detection
