摘要
糖尿病肾病(DKD)是糖尿病常见的并发症之一,主要特征为蛋白尿和肾小球滤过率降低。足细胞损伤是DKD发生发展过程中的重要环节,足细胞自噬与DKD密切相关。近年来,中医药治疗DKD具有独到见解,多种中药单体及复方能够有效缓解肾功能损害,阻断DKD进展,其机制可能是中医药多通路、多靶点调控足细胞自噬。本研究就中药单体及复方调控DKD足细胞自噬的研究展开阐述。
Diabetic kidney disease (DKD) is one of the common complications of diabetes,which is mainly characterized by proteinuria and decreased glomerular filtration rate.Podocyte autophagy,closely related to the disease,plays an important role in its occurrence and development.In recent years,traditional Chinese medicine has gained unique insights into the treatment of DKD.A variety of single or compound medicines can effectively alleviate the renal impairment and block the progression of DKD,whose mechanism may boil down to the fact that traditional Chinese drugs regulate podocyte autophagy through multiple pathways and targets.Herein,the paper presents a review on the regulation of podocyte autophagy in DKD by single or compound Chinese medicines.
作者
李明侠
李小会
LI Mingxia;LI Xiaohui(Shaanxi University of Chinese Medicine,Xianyang 712000,China)
出处
《长春中医药大学学报》
2022年第11期1289-1294,共6页
Journal of Changchun University of Chinese Medicine
基金
国家自然科学基金委员会资助项目(82074383)。
关键词
糖尿病肾病
足细胞
自噬
中药
diabetic nephropathy
podocyte
autophagy
Chinese materia medica
