摘要
目的系统评价孕期双酚A暴露与自然流产的相关性。方法计算机检索PubMed、Web of Science、EMbase、CNKI、WanFang Data和VIP数据库,搜集双酚A暴露和自然流产相关性的队列研究和病例-对照研究,检索时限均从建库至2022年4月1日,由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Stata 16.0软件进行Meta分析。结果共纳入7个病例-对照研究和1个队列研究,包括1179例研究对象。Meta分析结果显示,无论样本来源是血清还是尿液,病例组与对照组双酚A浓度的差异均有统计学意义[SMD_(血清)=1.05,95%CI(0.34,1.77),P=0.004;SMD_(尿液)=0.20,95%CI(0.02,0.38),P=0.027]。结论当前证据表明,孕期高水平的双酚A暴露可能是自然流产的危险因素之一。受纳入研究数量和质量限制,上述结论尚待更多高质量研究予以验证。
Objective To systematically review the association between exposure to bisphenol A during pregnancy and spontaneous abortion.Methods The PubMed,Web of Science,EMbase,CNKI,WanFang Data and VIP databases were electronically searched to identify cohort studies and case-control studies related to bisphenol A exposure and spontaneous abortion from inception to April 1st,2022.Two reviewers independently screened the literature,extracted data,and assessed the risk of bias of the included studies.Meta-analysis was then performed using Stata 16.0 software.Results A total of 7 case-control studies and 1 cohort study were included,with a total of 1179 subjects.The results of meta-analysis showed that there was a statistically significant difference in bisphenol A concentrations between the spontaneous abortion group and the control group regardless of whether the sample source was serum or urine(SMD_(serum)=1.05,95%CI 0.34 to 1.77,P=0.004;SMD_(urine)=0.20,95%CI 0.02 to 0.38,P=0.027).Conclusion The current evidence shows that exposure to bisphenol A during pregnancy may lead to unexplained recurrent spontaneous abortion.Due to the limited quantity and quality of the included studies,more high-quality studies are needed to verify the above conclusion.
作者
邹萱敏
陈晨
关添月
郝加虎
ZOU Xuanmin;CHEN Chen;GUAN Tianyue;HAO Jiahu(School of Public Health,Anhui Medical University,Hefei 230032,P.R.China;MOE Key Laboratory of Population Health Across Life Cycle,NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract,Anhui Provincial Key Laboratory of Population Health and Aristogenics,Hefei 230032,P.R.China)
出处
《中国循证医学杂志》
CSCD
北大核心
2022年第10期1149-1154,共6页
Chinese Journal of Evidence-based Medicine
基金
国家自然科学基金项目(编号:81872635、81573164)。
