摘要
目的探讨老年2型糖尿病患者三酰甘油葡萄糖(TyG)指数与骨密度(BMD)的相关性。方法纳入2019年1月至2021年12月在中南大学湘雅二医院老年医学科住院的老年2型糖尿病患者,获取一般临床资料,计算TyG指数,采用双能X线骨密度仪测定腰椎、股骨颈和总股骨BMD,采用多元线性回归分析TyG指数与BMD的相关性;Logistic回归分析TyG指数与骨质疏松症患病风险的关联。结果共纳入822例研究对象,在老年男性T2DM患者中,校正潜在影响因素后,多元线性回归分析结果显示,TyG指数与腰椎、股骨颈及总股骨BMD均呈正相关关系(β=0.465、0.348、0.317,P=0.004、0.031、0.022);在老年女性T2DM患者中,TyG指数与腰椎、股骨颈及总股骨BMD的相关性则无统计学意义(均P>0.05)。二分类Logistic回归分析结果显示,在老年男性T2DM患者中,校正潜在影响因素后,TyG指数是骨质疏松的保护因素(OR=0.349,95%CI:0.144~0.846,P=0.020);在老年女性T2DM患者中,TyG指数与骨质疏松的患病风险则无明显关联(OR=1.748,95%CI:0.782~3.912,P=0.174)。结论在老年男性T2DM患者中,用于评估胰岛素抵抗的TyG指数与腰椎、股骨颈和总股骨BMD密切相关,是骨质疏松患病的保护因素。
Objective To explore the relationship between triglyceride-glucose(TyG)index and bone mineral density(BMD)in elderly patients with type 2 diabetes mellitus(T2DM).Methods Elderly inpatients with T2DM in Department of Geriatrics of the Second Xiangya Hospital of Central South University were enrolled from January 2019 to December 2021.General clinical characteristics and the calculated TyG index were collected.BMDs at the lumbar spine,femoral neck,and total hip were measured using dual-energy X-ray absorptiometry.Multiple linear regression was used to detect the correlation between TyG index and BMDs;Logistic regression analysis was used to analyze the relationship between TyG index and osteoporosis(OP)risk.Results A total of 822 subjects were included in this study.In elderly men with T2DM,TyG index was significantly positively correlated with BMDs of lumbar spine(β=0.465,P=0.004),femoral neck(β=0.348,P=0.031)and total hip(β=0.317,P=0.022)after adjusting for confounders,but these results were not observed in elder women with T2DM(all P>0.05).Binary Logistic regression analysis showed that in elderly men with T2DM,after adjusting for confounders,the TyG index was a protective factor for osteoporosis(OR=0.349,95%CI:0.144-0.846,P=0.020).However,in elderly women with T2DM,the TyG index was not significantly associated with the risk of osteoporosis(OR=1.748,95%CI:0.782-3.912,P=0.174).Conclusions TyG index,which is used to evaluate insulin resistance,is strongly and correlated with BMDs of lumbar spine,femoral neck and total femoral in elderly male patients with T2DM,and is a protective factor for osteoporosis.
作者
李爽
詹俊鲲
Li Shuang;Zhan Junkun(Department of Geriatrics,Institute of Aging and Geriatrics,the Second Xiangya Hospital,Central South University,Changsha 410011,China)
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2022年第10期1167-1172,共6页
Chinese Journal of Geriatrics
基金
国家自然科学基金(82101663、81974223)。
关键词
糖尿病
2型
骨密度
骨质疏松
Diabetes mellitus,type 2
Bone density
Osteoporosis
