摘要
黄腐酚(XN)是啤酒花中特有的一种黄酮类化合物,可促进成骨细胞(OB)分化和抑制破骨细胞(OC)分化,调节骨代谢。本文通过检索近10年CNKI、维普、万方、pubmed等数据库相关文献,就XN参与OB和OC分化及相关信号通路的文献进行分析,结果表明XN可上调Runx2的表达,促进OB的增殖分化。并可下调PPARγ的表达,抑制脂肪细胞的分化,从而调节成骨与成脂分化平衡。同时,XN亦可通过上调Nrf2的表达促进体内抗氧化物的产生,从而减少氧化应激对OB的损害。另外,XN可抑制NF-κB、Ca^(2+)/NFATc1、MAPK等通路,抑制OC的分化成熟。通过综述进一步明确了XN调节骨代谢的作用机制,为开发防治骨质疏松症的药物提供新的靶点。
Xanthohumol(XN)is a special flavonoid in hops,which can promote osteoblast differentiation and inhibit osteocbast(OB)differentiation,and regulate osteoclast(OC)metabolism.In this paper,literatures related to the involvement of xanthohumol in OB and OC differentiation and related signal pathways were analyzed by searching CNKI,VIP,Wanfang,PubMed and other databases in the last 10 years.The results showed that XN could up-regulate the expression of Runx2 and promote the proliferation and differentiation of OB.In addition,the expression of PPARγwas down-regulated,and the differentiation of adipocytes was inhibited,thus regulating the balance of osteogenic and adipogenic differentiation.Meanwhile,XN can also promote the production of antioxidants in vivo by up-regulating Nrf2 expression,thus reducing the damage of oxidative stress to OB.In addition,XN inhibited NF-κB,Ca^(2+)/NFATc1,MAPK and other pathways,and inhibited OC differentiation and maturation.This review further clarified the mechanism of XN regulating bone metabolism,and provided a new target for the development of drugs for the prevention and treatment of osteoporosis.
作者
赵怡凡
刘天鹏
赵少川
芮琛
杨锋
ZHAO Yifan;LIU Tianpeng;ZHAO Shaochuan;RUI Chen;YANG Feng(Graduate School,Shaanxi University of Chinese Medicine,Shanxi Province,Xianyang 712000,China;Department of Orthopedics,Affiliated Hospital of Shaanxi University of Chinese Medicine,Shanxi Province,Xianyang 712000,China)
出处
《中国医药导报》
CAS
2022年第29期34-37,45,共5页
China Medical Herald
基金
国家自然科学基金资助项目(81973889)
陕西高校青年创新团队(陕教〔2019〕90号)
陕西省中医药管理局中医药传承创新暨“秦药”开发重点科学研究项目(2021-01-22-009)。
