摘要
目的:探究双水平正压通气模式(BIPAP)联合特布他林雾化吸入对老年性重症哮喘合并呼吸衰竭患者的治疗效果,以及对其肺功能、免疫功能的影响。方法:选取2019年4月~2022年1月在本院接受治疗的老年性重症哮喘合并呼吸衰竭患者121例,采用随机数表法分为观察组(59例)和对照组(62例)。对照组患者采用常规治疗措施以及特布他林雾化吸入,观察组患者在其基础上联合BIPAP治疗,对比两组患者的相关参数。结果:观察组患者咳嗽、气促、住院时间短于对照组,住院总费用低于对照组;治疗后,观察组患者的肺功能指标第一秒呼出的气量容积(FEV1)、呼气峰流速(PEF)以及动脉血氧分压(PaO_(2))高于对照组,免疫功能指标白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、检测嗜酸性粒细胞比例(EOS)以及血气指标动脉二氧化碳分压(PaCO_(2))低于对照组;治疗后3 d、6 d,观察组患者的呼吸困难指数(mMRC)低于对照组。结论:BIPAP联合特布他林雾化吸入治疗可有效改善老年性重症哮喘合并呼吸衰竭患者的肺功能和炎症反应,缩短患者的住院时间、缓解其呼吸困难症状,值得在临床中推广应用。
Objective To explore the therapeutic effects of bilevel positive airway pressure (BIPAP) combined with terbutaline aerosol inhalation in the treatment of senile severe asthma with respiratory failure,and its influence on lung function and immune function.Methods A total of 121 elderly patients with severe asthma and respiratory failure treated in the hospital were enrolled in this study between April 2019 and January 2022.They were divided into observation group (n=59) and control group (n=62) by random number table method.Patients in the control group were given conventional treatments and terbutaline aerosol inhalation,while patients in the observation group were treated with BIPAP based on the treatments of control group.The relevant parameters were compared between the two groups.Results The duration of cough,shortness of breath,and the length of hospital stay of the observation group were shorter than those of the control group,and the total hospitalization cost was less than that of the control group.After treatment,the forced expiratory volume in 1s (FEV1),peak expiratory flow (PEF),and arterial partial pressure of oxygen (PaO2) in the observation group were higher than those in the control group,while interleukin-6(IL-6),tumor necrosis factor-α (TNF-ɑ),eosinophil ratio (EOS) and arterial partial pressure of carbon dioxide (PaCO2) were lower than those in the control group.At 3 and 6 days after treatment,the modified Medical Research Council (mMRC) dyspnea scores of the observation group were lower than those of the control group.Conclusion BIPAP combined with terbutaline aerosol inhalation can effectively improve lung function and inflammatory response in elderly patients with severe asthma and respiratory failure,shorten the length of hospital stay,and relieve dyspnea symptoms.
作者
肖影
青刚
Xiao Ying;Qing Gang(West China Guang’an Hospital of Sichuan University,Guang'an 638500,China)
出处
《晓庄学院学报（医学版）》
2022年第4期77-81,共5页
Journal of Hunan Normal University(Medical Sciences)
基金
四川省卫生健康委员会科研课题(20PJ310)。
