摘要
目的:评价支气管扩张(BE)合并感染患者通过纤支镜灌注伊诺舒注射液治疗的疗效,并观察氧化应激、炎症因子、动脉血气与肺功能变化情况。方法:纳入彭州市人民医院2019年4月~2021年3月收治的BE合并感染患者的临床资料,共104例,根据治疗方法差异分为参照组(n=50)和纤支镜组(n=54),均予以支持性治疗,参照组在支持性治疗上加用伊诺舒静滴治疗,纤支镜组在伊诺舒静滴治疗3d后另通过纤支镜灌注伊诺舒治疗,均连续治疗14d后评估临床疗效,并观察治疗前后氧化应激、炎症因子、动脉血气与肺功能变化。结果:纤支镜组有效率(92.59%)明显高于参照组(72.00%);治疗前,两组各实验室指标及呼吸、肺功能参数对比未见显著差异。治疗后,两组患者肺泡灌洗液超氧化物歧化酶(SOD)明显升高,丙二醇(MDA)、肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6、IL-1β 均明显下降,动脉血氧饱和度(SaO_(2))、动脉血氧分压(PaO_(2))、肺活量(FVC)、第一秒用力呼吸量(FEV1)、呼气峰流速(PEF)均明显升高,动脉血二氧化碳分压(PaCO_(2))明显下降,且纤支镜组上述指标均显著优于参照组。结论:BE合并感染通过纤支镜灌注伊诺舒注射液治疗,可获得突出疗效,这与通过纤支镜灌注伊诺舒能积极调控氧化应激、缓解气道炎症反应、调节动脉血气与肺功能有关。
Objective To evaluate the curative effect of perfusion of ambroxol hydrochloride injection through fiberoptic bronchoscope on bronchiectasis (BE) with infection,and observe the changes in oxidative stress,inflammatory factors,arterial blood gas and pulmonary function.Methods The clinical data of 104 patients with BE and infection who were admitted to Pengzhou People’s Hospital between April 2019 and March 2021 was was retrospectively analyzed.The patients were divided into reference group (n=50) and fiberoptic bronchoscope group (n=54) according to different treatment methods.All patients were treated with supportive treatment.On this basis,the reference group was treated with intravenous drip of mbroxol hydrochloride injection,and the fiberoptic bronchoscope group was treated with perfusion of ambroxol hydrochloride injection through fiberoptic bronchoscope after 3d of intravenous drip.Clinical effect was evaluated after 14d of treatment,and observe the changes in oxidative stress,inflammatory factors,arterial blood gas and pulmonary functio.Results The clinical response rate of the fiber bronchoscope group (92.59%) was significantly different from that of the control group (72.00%).Before treatment,there was no statistically significant difference between the two groups in laboratory indexes,respiratory and pulmonary function indexes.After treatment,superoxide dismutase (SOD) in alveolar lavage fluid,Arterial oxygen saturation (SaO_(2)),arterial partial pressure of oxygen (PaO_(2)),vital capacity (FVC),First second (FEV1) and Peak expiratory flow rate (PEF) were significantly increased,MDA,Tumor necrosis factor (TNF)-α,Interleukin IL-6,IL-1β and Arterial partial pressure of carbon dioxide (PaCO_(2)) were significantly decreased in the two groups.The above-mentioned indexes in observation group were significantly better than those in the control group.Conclusion Perfusion of ambroxol hydrochloride injection through fiberoptic bronchoscope is effective in the treatment of BE with infection,which is related to active regulation of oxidative stress,relief of airway inflammatory response,arterial blood gas and pulmonary function.
作者
任晓慧
文璐
张勇
李晓艳
杨柳
Ren Xiao-hui;Wen Lu;Zhang Yong;Li Xiao-yan;Yang Liu(Department of Respiratory and Critical Care Medicine,Pengzhou People’s Hospital,Pengzhou 611900,China)
出处
《晓庄学院学报（医学版）》
2022年第4期12-15,共4页
Journal of Hunan Normal University(Medical Sciences)
基金
四川卫生厅基金项目(17PJ4008)。
关键词
伊诺舒
纤支镜
支气管扩张
感染
氧化应激
炎症反应
动脉血气
ambroxol hydrochloride injection
fiberoptic bronchoscope
bronchiectasis
infection
oxidative stress
inflammatory response
arterial blood gas
