摘要
不孕不育已经成为影响人类健康和人口数量的重大疾病,而男性不育症是不孕不育的一个主要原因。类器官是利用细胞的自组装能力,经体外培养发育成能够模拟体内器官结构功能的组织或器官,其对于男性生殖系统疾病的研究与治疗意义重大。男性生殖类器官是研究生殖细胞生态位及细胞信号转导通路的强有力的模型系统,为研究人类精子发生的分子机制提供新思路。肿瘤导致的功能障碍严重影响正常精子的产生,类器官还可以建立生殖系统中肿瘤与不同疾病的体外模型,为疾病的预防与治疗提供新途径。类器官培养体系建立是个逐渐发展进步的过程,培养方法复杂多样。本文主要综述男性生殖系统类器官(包括睾丸类器官、附睾类器官、前列腺类器官)的最新研究进展以及未来的发展方向,以期推进男性生殖类器官的发展及应用。
Infertility has become a serious disease affecting human health and population,and male infertility is a main reason for this disease.Organoids,by definition,are the tissues or organs derived from the cells with the assembly ability to culture,and they can mimic the architecture and function of organs in vivo.Notably,organoids are of great significance for the research of male reproductive system diseases.Male reproductive organoids are a powerful and excellent model system for examining germ cell niches and intracellular transduction pathways,and they could provide novel concepts for exploring molecular mechanisms of human spermatogenesis.Tumors result in the dysfunction of reproductive organs,which seriously affects the production of normal sperm.Organoids can also establish a model of tumors and different diseases of the reproductive system in vitro,which provides new approaches for disease prevention and treatment.The establishment of organoids’ culture system has been gradually developed,while the culture methods are complex and diverse.In this review,we address the latest research progress and future directions of male reproductive organoids,including testis organoids,prostrate organoids,epididymis organoids,with an aim to promote the development and applications of male reproductive organoids.
作者
张栋
杜黎
何祖平
Zhang Dong;Du Li;He Zu-ping(School of Medicine,Human Normal University,Changsha 410013,China)
出处
《晓庄学院学报（医学版）》
2022年第4期1-6,共6页
Journal of Hunan Normal University(Medical Sciences)
基金
国家自然科学基金项目(32170862)。
关键词
睾丸类器官
附睾类器官
前列腺类器官
三维培养
testis organoids
prostrate organoids
epididymis organoids
three-dimensional culture
