摘要
目的 分析予以妊娠合并糖尿病(gestational diabetes mellitus,GDM)患者地特胰岛素+门冬胰岛素治疗的临床效果。方法 选择2018年1月—2022年5月在徐州市矿山医院接受治疗的40例GDM患者为研究对象,依据随机数表法将其分为对照组(20例,门冬胰岛素+精蛋白生物合成人胰岛素治疗)和观察组(20例,地特胰岛素+门冬胰岛素治疗)。对比两组患者治疗效果。结果 观察组空腹血糖(FPG)、餐后2 h血糖(2 hPG)及二者均达标时间为(4.85±2.12)、(5.70±2.34)、(6.87±3.21)d,短于对照组的(7.12±2.31)、(8.75±3.15)、(10.85±2.46)d,差异有统计学意义(t=3.238、3.476、4.401,P<0.05);治疗后,观察组FPG、2 hPG水平均低于对照组,差异有统计学意义(P<0.05);观察组网膜素1(Omentin-1)高于对照组,同型半胱氨酸(Hcy)水平、胰岛素抵抗指数(HOMA-IR)低于对照组,差异有统计学意义(P<0.05)。观察组母婴不良结局发生率为20.00%,低于对照组的50.00%,差异有统计学意义(χ~2=3.956,P<0.05)。结论 GDM患者予以地特胰岛素联合门冬胰岛素治疗效果显著,可缩短血糖达标时间,改善患者血糖水平及母婴结局。
Objective To analyze the clinical effect of insulin detemir + insulin aspart in patients with gestational diabetes mellitus(GDM).Methods From January 2018 to May 2022,40 patients with GDM who were treated in Xuzhou Mining Hospital were selected as the research objects.According to the random number table method,they were divided into control group(20 cases,insulin aspart + protamine biosynthesis human insulin treatment) and observation group(20 cases,insulin detemir + insulin aspart treatment).The treatment effects of the two groups of patients were compared.Results The time when the fasting blood glucose(FPG),2 h postprandial blood glucose(2 hPG) and both reached the standard in the observation group were(4.85±2.12) d,(5.70±2.34) d,(6.87±3.21) d shorter than the control group(7.12±2.31) d,(8.75±3.15) d,(10.85±2.46) d,and the difference was statistically significant(t=3.238,3.476,4.401,P<0.05).After treatment,the levels of FPG and 2 hPG in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Omentin-1 in the observation group was higher than that in the control group,and the level of homocysteine(Hcy) and the insulin resistance index(HOMA-IR) in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of maternal and infant adverse outcomes in the observation group was 20.00%,which was lower than 50.00% in the control group,and the difference was statistically significant(χ~2=3.956,P<0.05).Conclusion Insulin detemir combined with insulin aspart has a significant effect on GDM patients,which can shorten the time to reach the blood glucose target and improve the blood glucose level and maternal and infant outcomes.
作者
于光霏
李晶
张金银
YU Guangfei;LI Jing;ZHANG Jinyin(Department of Obstetrics and Gynecology,Xuzhou Mining Hospital,Xuzhou,Jiangsu Province,221000 China)
出处
《糖尿病新世界》
2022年第17期98-100,104,共4页
Diabetes New World Magazine
