摘要
In a recent study published in science,Spadaro and colleagues described the downregulation of PLA2G7 through sustained calory restriction as a crucial factor for lowering inflammatory mechanisms and contributing to longevity.PLA2G7’s identification as a critical regulatory gene is important to better understand the role of adipose tissue metabolism in regulating immune-metabolic effects.These data show that long-term calorie restriction(CR)improves health and extends life expectancy.1 Chronic 40%CR increases susceptibility to infections in mice,shortening their lifespan.In contrast,the Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy(CALERIE)analysis found that moderate CR in humans over 24 months did not reduce immune functions.14%sustained CR was associated with improved adipose tissue metabolism,decreased inflammation,and reduced thymic lipoatrophy.Spadaro et al.discovered that low platelet activating factor acetyl hydrolase(PLA2G7)correlates with immune-metabolic consequences of CR and contributes to decreased inflammation and a longer lifespan in healthy mid-aged adults.1 PLA2G7 is a lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress responses.
基金
Open Access funding enabled and organized by Projekt DEAL.
