摘要
目的:观察中药扶正化痰解毒方对惰性B细胞淋巴瘤病程进展的影响及其可能机制。方法:将诊断为惰性B细胞淋巴瘤的109例患者,随机分为两组。治疗组67例,对照组42例;治疗组予中药扶正化痰解毒方,3个月为1个疗程,对照组予定期随访观察。治疗组47例住院患者每3个月检查1次相关观察指标,连续观察3年。结果:治疗组3年内进入西医干预人数明显少于对照组(P﹤0.001);治疗组47例住院患者治疗后中医证候学积分较前明显降低(P﹤0.05);治疗组47例住院患者治疗后较治疗前CD4/CD8明显升高(P﹤0.05),VEGF、TNF-α明显降低(P﹤0.05)。结论:扶正化痰解毒方能够有效延缓惰性B细胞淋巴瘤患者进入西医干预阶段,且能够减轻患者的相关临床症状,改善生存质量。
Objective:To observe the effect of Chinese herbal medicine Fuzheng Huatan Jiedu formula on the disease progression of indolent B-cell lymphoma and its possible mechanism.Methods:109 cases of diagnosed patients with indolent B-cell lymphoma were randomly divided into 2 groups,67 cases in treatment group,42 cases in control group.The treatment group was treated with Chinese herbal medicine Fuzheng Huatan Jiedu formula,3 months as a course of treatment,while the control group was regularly followed up and observed.For 47 cases of inpatients in treatment group,the relevant observed indexes were examined once every 3 months,and continuously observed for 3 years.Results:The number of patients in treatment group who entered into western medicine intervention within 3years was significantly less than that in control group(P<0.001).Some of TCM syndrome scores of 47 inpatients in treatment group after treatment were significantly lower than before treatmetn(P<0.05).CD4/CD8 of 47 inpatients in treatment group after treatment was significantly increased compared with before treatment(P<0.05),VEGF and TNF-αwere significantly decreased(P<0.05).Conclusion:Fuzheng Huatan Jiedu formula can effectively delay indolent B-cell lymphoma entering into the stage of western medicine intervention,and relieve the patients’related clinical symptoms and improve the quality of life.
作者
武昊明
李希
甘欣锦
徐旻
沈伟
傅华
袁欣蓓
周雯怡
WU Hao-ming;LI Xi;GAN Xin-jin(Shanghai University of Traditional Chinese Medicine,Shanghai 210302,China;不详)
出处
《山西中医》
2022年第10期19-21,共3页
Shanxi Journal of Traditional Chinese Medicine
关键词
惰性B细胞淋巴瘤
扶正化痰解毒方
西医干预
中医药疗法
indolent B-cell lymphoma
Fuzheng Huatan Jiedu formula
western medicine intervention
therapy of TCM
