摘要
背景现有的磁控胶囊胃镜存在诸多不足,如分辨率和拍摄帧率低,通过食管时的速度不可控而无法全面观察食管,且存在胶囊内镜滞留的风险.新型系线式磁控胶囊内镜可实现高帧率、高分辨率,能全面观察食管且无胶囊滞留风险.目的通过动物实验验证一种新型系线式磁控胶囊内镜对食管和胃检查的可行性和安全性.方法对3只巴马小型猪先后行磁控胶囊内镜和传统胃镜检查,记录食管和胃的检查时间,评估磁控胶囊内镜在食管和胃的各个部位(食管上、中、下段、齿状线、贲门、胃底、胃体、胃角、胃窦、幽门)的可控性和粘膜可视度.分析实验动物检查前、后的血常规和生化指标,观察实验过程中的不良反应.结果与传统胃镜相比,磁控胶囊内镜在食管检查时间上无显著差异(104.67 s±7.02 s vs 88.33 s±3.51 s,P=0.093),对胃的检查耗时较长(25.67 min±5.69 min vs 6.00 min±1.00 min,P=0.019).磁控胶囊内镜的可控性和粘膜可视度在食管、齿状线、胃体、胃窦及幽门处较好,在贲门和胃底处稍差.实验动物无明显不良反应发生.结论这一新型的系线式磁控胶囊内镜对猪食管和胃的检查具有良好的可行性和安全性.
BACKGROUND Currently used magnetically controlled capsule gastroscope has many shortcomings,such as low resolution and frame rate,incomplete examination of the esophagus due to rapid passage,and risk of capsule retention.A novel string magnetically controlled capsule endoscopy with high frame rate and resolution can examine the esophagus comprehensively,and has no risk of capsule retention.AIM To verify the feasibility and safety of a novel string magnetically controlled capsule endoscopy for esophageal and gastric examination by animal experiments.METHODS Magnetically controlled capsule endoscopy(MCE)and traditional gastroscopy were performed on three Bama minipigs successively.The examination time for the esophagus and stomach was recorded.The MCE maneuverability and mucosal visualization in each part of the esophagus and stomach(upper,middle,and lower part of the esophagus,Z-line,and gastric cardia,fundus,body,angulus,antrum,and pylorus).Routine blood and biochemistry parameters of experimental animals before and after examination were analyzed,and adverse reactions occurring during the experiment were recorded.RESULTS Compared with traditional gastroscopy,MCE showed no significant difference in esophageal examination time(104.67 s±7.02 s vs 88.33 s±3.51 s,P=0.093).The gastric examination time of MCE was longer than that of traditional gastroscopy(25.67 min±5.69 min vs 6.00 min±1.00 min,P=0.019).The MCE maneuverability and mucosal visualization were better in the esophagus,Z-line,and gastric body,antrum,and pylorus than in the gastric cardia and fundus.No obvious adverse reactions occurred in experimental animals.CONCLUSION The novel string magnetically controlled capsule endoscopy has satisfactory feasibility and safety for esophageal and gastric examination in the porcine model.
作者
李燕
闫婧爽
闫斌
孟科
Yan Li;Jing-Shuang Yan;Bin Yan;Ke Meng(Department of Gastroenterology and Hepatology,The First Medical Center,Chinese PLA General Hospital,Beijing 100853,China;School of Medicine,Nankai University,Tianjin 300071,China)
出处
《世界华人消化杂志》
CAS
2022年第18期795-802,共8页
World Chinese Journal of Digestology
基金
国家重点研发计划,No.2019YFC0120303.
关键词
胶囊内镜
动物实验
可行性研究
Capsule endoscopy
Animal experimentation
Feasibility
