摘要
目的探究乳腺癌手术后患者开展三维调强放疗与三维适形放疗的作用。方法选择河南科技大学第一附属医院2019年1月至2021年12月收治的80例乳腺癌患者。按照放疗方式不同分为常规组(40例),试验组(40例)。全部患者均开展乳腺癌根治手术治疗,在手术后,将三维适形放疗应用于常规组患者中,将三维调强放疗应用于试验组患者中。针对每组患者肺受量、心脏指数、靶区剂量及不良反应进行比较。结果在V5、V10、V20、V30、V40及V50方面,试验组肺受量相较于常规组低,差异有统计学意义(P<0.05)。在心脏V30、V40及V50方面,试验组心脏受量相较于常规组低;在对侧乳腺平均剂量方面,试验组心脏受量相较于常规组低,差异有统计学意义(P<0.05)。在V115、V110及V105方面,试验组靶区剂量相较于常规组低;在靶区适形性方面,试验组相较于常规组高;在均匀指数方面,试验组相较于常规组低,差异有统计学意义(P<0.05)。在放射性肺炎、放射性皮炎、白细胞下降及放射性食管炎出现率方面,试验组患者分别是10.00%、12.50%、30.00%、2.50%,常规组患者分别是45.00%、47.50%、62.50%、25.00%,试验组相较常规组低,差异有统计学意义(P<0.05)。结论乳腺癌手术后患者选择三维调强放疗,能够降低肺部损伤、心脏损伤及靶区剂量,减少不良反应,安全性良好,可满足临床对治疗有效性及安全性的需求。
Objective To explore the role of 3 D IMRT and 3 D conformal radiotherapy after breast cancer surgery.Methods A total of 80 breast cancer patients admitted to the First Affiliated Hospital of Henan University of Science and Technology from January 2019 to December 2021 were selected.According to the radiotherapy method,they were divided into conventional group(40 cases)and test group(40 cases).All patients underwent radical surgery for breast cancer surgery.After surgery,3D conformal radiotherapy was applied to patients in the conventional group,and 3 D IMRT was applied to patients in the trial group.The lung volume,cardiac index,target area dose and adverse effects were compared between two groups.Results In terms of V5,V10,V20,V30,V40,and V50,lower lung volume in the test group compared to the conventional group,the difference was significantly significant(P<0.05).In terms of heart V30,V40 and V50,the cardiac volume in the test group was lower compared with the conventional group;In terms of the average contralateral breast dose,the cardiac volume was lower compared to the conventional group,the differences were significantly significant(P<0.05).In terms of V115,V110 and V105,the target area dose of test group was lower than that of conventional group,in terms of target area conformation,the test group was higher than the conventional group;in terms of the homogeneous index,the test group was lower than the conventional group,the differences were significantly significant(P<0.05).In terms of the rates of radiation pneumonia,radiation dermatitis,leukocyte drop,and radiation esophagitis,they were 10.00%,12.50%,30.00%,2.50%in test group,45.00%,47.50%,62.50%,and 25.00%in conventional group,which were lower in the test group compared with conventional group,the differences were significantly significant(P<0.05).Conclusion Three-dimensional IMRT after breast cancer surgery can reduce lung injury,heart injury and target area dose,reduce adverse reactions,with good safety,and meet the clinical needs for therapeutic effectiveness and safety.
作者
许艳
XU Yan(Department of Radiotherapy,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang Henan 471000,China)
出处
《临床研究》
2022年第11期19-22,共4页
Clinical Research
关键词
乳腺癌
三维调强放疗
三维适形放疗
肺受量
不良反应
靶区剂量学
breast cancer
3D IMRT
3D conformal radiotherapy
lung volume
adverse reactions
target region dosimetry
