摘要
目的探讨血清补体C3、C4及甲胎蛋白(AFP)水平与肝癌经导管动脉栓塞化疗(TACE)患者疗效及预后的关系。方法选取112例肝癌TACE治疗患者,检测治疗前后血清补体C3、C4及AFP水平,分析各指标与患者TACE疗效、术后1年生存情况的关系。结果术后1周,肝癌TACE患者血清AFP水平低于本组术前(P<0.05);术后1个月,肝癌TACE患者血清补体C3、C4水平均高于本组术前及术后1周时,AFP水平均低于本组术前及术后1周时,差异均有统计学意义(P<0.05)。112例肝癌患者均顺利完成TACE手术,治疗总有效率为32.14%。将完全缓解+部分缓解患者作为有效组(n=36),疾病稳定+疾病进展患者作为无效组(n=76),术后1个月,有效组患者血清补体C3、C4水平均高于无效组,AFP水平低于无效组,差异均有统计学意义(P<0.05)。Spearman相关分析显示,补体C3、C4与TACE疗效均呈正相关(r=0.473、0.447,P<0.05),AFP与TACE疗效呈负相关(r=-0.629,P<0.05);补体C3、C4与肝癌TACE患者术后1年生存情况均呈正相关(r=0.343、0.360,P<0.05),AFP与肝癌TACE患者术后1年生存情况呈负相关(r=-0.410,P<0.05)。补体C3、C4及AFP预测肝癌患者TACE疗效的曲线下面积(AUC)分别为0.694、0.680、0.682,其中以补体C3的AUC最大。结论肝癌患者接受TACE治疗后,血清补体C3、C4水平升高,AFP水平降低,补体C3、C4及AFP水平变化与肝癌TACE疗效及预后有关。
Objective To investigate the relationship between serum complement C3,C4,alpha-fetoprotein(AFP)levels and the efficacy and prognosis of patients with liver cancer treated by transcatheter arterial chemoembolization(TACE).Method A total of 112 patients with liver cancer treated with TACE were selected.Serum complement C3,C4,and AFP levels were detected before and after the treatment.The relationship between each indicator and the efficacy of TACE and 1-year survival after surgery was analyzed.Result One week after the operation,the serum AFP level of TACE patients with liver cancer was lower than that before the operation(P<0.05).One month after the operation,the levels of serum complement C3 and C4 in TACE patients with liver cancer were higher than those before the operation and 1week after the operation,while the AFP levels were lower than those before the operation and 1 week after the operation,and the differences were statistically significant(P<0.05).All 112 patients with liver cancer successfully completed TACE,and the total effective rate was 32.14%.The patients with complete remission and partial remission were taken as the effective group(n=36),and the patients with stable disease and progressive disease were taken as the ineffective group(n=76).One month after the operation,the serum levels of complement C3 and C4 in the effective group were higher than those in the ineffective group,the AFP level was lower than that of the ineffective group,and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that complement C3 and C4 were positively correlated with the efficacy of TACE(r=0.473,0.447,P<0.05),and AFP was negatively correlated with the efficacy of TACE(r=-0.629,P<0.05).Complement C3 and C4 were positively correlated with one-year survival of liver cancer TACE patients(r=0.343,0.360,P<0.05),and AFP was negatively correlated with one-year survival of liver cancer TACE patients(r=-0.410,P<0.05).The area under the curve(AUC)of complement C3,C4,and AFP for predicting the efficacy of TACE in patients with liver cancer were 0.694,0.680,and 0.682,respectively,and the AUC of complement C3 was the largest.Conclusion After TACE treatment,the serum levels of complement C3 and C4 increased,while the level of AFP decreased in liver cancer patients.The alternations of complement C3,C4,and AFP levels are related to the efficacy of TACE and the prognosis of patients with liver cancer.
作者
余秉贤
冉绍云
王仕海
王峰
YU Bingxian;RAN Shaoyun;WANG Shihai;WANG Feng(Department of Medical Laboratory,Zhengzhou First People’s Hospital,Zhengzhou 450000,He’nan,China)
出处
《癌症进展》
2022年第17期1821-1824,1828,共5页
Oncology Progress
关键词
原发性肝癌
经导管动脉栓塞化疗
血清补体
甲胎蛋白
primary liver cancer
transcatheter arterial chemoembolization
serum complement
alpha-fetoprotein
