摘要
目的:探讨血清Apelin-13水平与2型糖尿病骨质疏松患者骨代谢相关性。方法:选取120例2型糖尿病患者,依据世界卫生组织骨质疏松诊断标准将其分为骨量正常组(n=45)、骨量减少组(n=40)和骨质疏松组(n=35)。对比各组患者的临床资料、实验室指标(骨代谢、血糖水平),并采用Pearson分析血清Apelin水平与患者骨代谢标志物的相关性。结果:血清Apelin-13、总Ⅰ型胶原氨基端肽(T-P1NP)、25羟维生素D[25(OH)D]水平比较:骨质疏松组<骨量减少组<骨量正常组(P<0.05);血清Ⅰ型胶原羧基端肽(β-CTX)、骨钙素(BGP)水平比较:骨质疏松组>骨量减少组>骨量正常组(P<0.05)。Pearson相关性分析:血清Apelin与T-P1NP、BGP、25(OH)D水平呈正相关,与β-CTX水平呈负相关(P<0.05)。结论:2型糖尿病骨质疏松患者的血清Apelin-13、骨代谢水平均异常且具有一定的相关性,通过血清Apelin水平检测有助于评估糖尿病患者骨质疏松发生的风险。
Objective:To explore the correlation between serum Apelin-13 level and bone metabolism in type 2 diabetic osteoporosis patients.Methods:120 patients with type 2 diabetes were divided into normal bone mass group(n=45)and osteopenic group(n=40),osteoporosis group(n=35)according to the diagnostic criteria of osteoporosis of the World Health Organization.Collect patients5 clinical data and laboratory indicators(bone metabolism,blood glucose level)for comparison,and use Pearson to analyze the correlation between serum Apelin levels and bone metabolism markers.Results:The levels of Apelin-13,total type I collagen amino terminal peptide(T-P1NP),25-hydroxyvitamin D3[25(OH)D3]in the osteoporosis group<osteopenia group<normal bone mass group(P<0.05).The level of type I collagen carboxy-terminal peptide(p-CTX)and osteocalcin(BGP)in the osteoporosis group>the osteopenia group>the normal bone mass group(P<0.05).According to Pearson correlation analysis,Serum Apelin was positively correlated with T-P1NP,BGP,25(OH)D3,and negatively correlated with p-CTX(P<0.05).Conclusion:The serum Apelin-13 and bone metabolism levels of type 2 diabetic osteoporosis patients are abnormal and have a certain correlation.The detection of serum Apelin level helps to assess the risk of osteoporosis in diabetic patients.
作者
韩旸
王凯亮
邵楠
李洪梅
HAN Yang;WANG Kai-liang;SHAO Nan;LI Hong-mei(Department of Endocrinology,Emergency General Hospital,Beijing 100028,China;Department of Orthopaedics,Emergency General Hospital,Beijing 100028,China)
出处
《川北医学院学报》
CAS
2022年第9期1124-1126,1130,共4页
Journal of North Sichuan Medical College
基金
北京市卫生健康科研课题(20210073)。
