摘要
Wound healing has invariably been a fundamental health concern,demanding manpower and materials and causing financial burdens.In this research,inspired by the hemostatic function of platelets,we proposed a novel bionic hydrogel by covalent amidation crosslinking natural platelet and alginate for wound healing.With the natural functional groups,the platelet-derived hydrogel exhibited outstanding biocompatibility and blood compatibility.By changing the addition ratio of platelets to alginates,the mechanical properties of the achieved hydrogel were variable to cater to different wound environments.Furthermore,silver nanoparticles could be loaded into the void space of the hydrogel which endowed the composites with superior anti-infective properties.We have demonstrated that the bio-inspired platelet hydrogel could promote hemostasis of acute tissue damage,prevent bacterial proliferation,and promote angiogenesis,collagen deposition,and granulation tissue formation in wound healing.These features signify the potential values of the bio-inspired platelet hydrogel in clinical applications.
伤口愈合始终是一个基本的健康问题,需要消耗大量人力和物力,并造成经济负担.受血小板止血功能的启发,本文采用共价酰胺化方法将天然血小板与海藻酸盐交联,制成一种新型的用于伤口愈合的仿生水凝胶.血小板水凝胶具有良好的生物相容性和血液相容性.通过改变血小板与海藻酸盐的添加比例,以获得不同力学性能的水凝胶,进而适应不同伤口环境.此外,银纳米颗粒可以被加载到水凝胶的空隙中,这使复合材料具有更好的抗感染性能.基于生物启发的血小板水凝胶可以有效解决急性组织损伤后的出血问题,防止细菌增殖,促进伤口愈合中的血管生成、胶原沉积和肉芽组织形成.这些特征表明了生物仿生血小板水凝胶在临床应用中的潜在价值.
作者
Yuanyuan Jiang
Jie Wang
Hui Zhang
Guopu Chen
Yuanjin Zhao
姜媛媛;王洁;张慧;陈国璞;赵远锦(Department of Rheumatology and Immunology,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing University,Nanjing 210096,China;Children’s Hospital of Nanjing Medical University,Nanjing 210008,China;College of Artificial Intelligence,Nanjing Agricultural University,Nanjing 210031,China;State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China)
基金
supported by the National Key Research and Development Program of China(2020YFA0908200)
the National Natural Science Foundation of China(52073060 and 22002061)
the Natural Science Foundation of Jiangsu(BK20200551)
the Shenzhen Fundamental Research Program(JCYJ20190813152616459 and JCYJ20210324133214038)。
