摘要
The pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has led to major public health challenges globally.The increasing viral lineages identified indicate that the SARS-CoV-2 genome is evolving at a rapid rate.Viral genomic mutations may cause antigenic drift or shift,which are important ways by which SARS-CoV-2 escapes the human immune system and changes its transmissibility and virulence.Herein,we summarize the functional mutations in SARS-CoV-2 genomes to characterize its adaptive evolution to inform the development of vaccination,treatment as well as control and intervention measures.
基金
supported by the Medical and Health Science and Technology Innovation Project of Chinese Academy of Medical Sciences(No.2021-I2M-1-040)。
