摘要
目的:探究两种不同手术方式治疗结直肠癌的疗效及对血清指标学的影响。方法:选取98例结直肠癌患者进行研究,按照随机数字法均分为对照组(传统开腹手术治疗)和观察组(腹腔镜根治术治疗),每组49例。比较两组患者临床指标、血清指标学水平、不良反应发生率。结果:观察组手术时间、术中出血量、首次排气时间、住院时间,均低于对照组,差异有统计学意义(P<0.05)。术前,两组血清指标水平比较,差异无统计学意义(P>0.05)。术后,观察组超氧化物歧化酶(SOD)、人脂联素(ADPN)、转铁蛋白(TRE)、清蛋白(ALB)、前清蛋白(PA)、视黄醇蛋白(RBP)指标水平高于对照组,血清丙二醛(MDA)、血清降钙素原(PCT)指标水平低于对照组,差异有统计学意义(P<0.05)。同时与术前相比较,术后患者SOD、ADPN、TRE、ALB、PA、RBP指标水平有所减低,MDA、PCT指标水平上升,差异有统计学意义(P<0.05)。术后,观察组与对照组不良反应发生率比较,差异有统计学意义(P<0.05)。结论:采用腹腔镜手术治疗结直肠癌患者,可以减少术中出血量,提高疗效,稳定血清水平。
Objective To explore the efficacy of two different surgical methods in the treatment of colorectal cancer and its impact on serum indicators.Method 98 patients with colorectal cancer were selected for study. They were randomly divided into control group(traditional open surgery) and observation group(laparoscopic radical surgery). There were 49 patients in each group. The statistical differences of clinical indexes, serum index level and incidence of adverse reactions between the two groups were compared.Results The operation time, intraoperative bleeding, first exhaust time and hospital stay in the observation group were lower than those in the control group, and the differences were statistically significant(P<0.05). Before operation, there was no significant difference between the two groups(P>0.05). After operation, the levels of SOD, ADPN, TRE, ALB, PA and RBP in the observation group were lower than those in the control group(P<0.05). At the same time, compared with before operation, the levels of SOD, ADPN,TRE, ALB, PA and RBP decreased, while the levels of MDA and PCT increased(P<0.05). After operation, the incidence of adverse reactions was significantly higher in the observation group and the control group(P<0.05).Conclusion Laparoscopic surgery can reduce the amount of intraoperative bleeding, improve the curative effect and stabilize the serum level in patients with colorectal cancer.
作者
黄蒙
曾晓奇
苏晓文
HUANG Meng;ZENG Xiao-qi;SU Xiao-wen(Department of Gastrointestinal Surgery,Gaozhou People′s Hospital,Gaozhou 525200,China)
出处
《吉林医学》
CAS
2022年第9期2369-2372,共4页
Jilin Medical Journal
关键词
腹腔镜
结直肠癌
根治术
血清水平
Laparoscope
Colorectal cancer
Radical operation
Serum level
