摘要
The development of an efficient and sustainable synthetic route for formaldehyde production from renewable feedstock,especially in combination with a subsequent transformation to straightforwardly construct valuable chemicals,is highly desirable.Herein,we report a novel manganese-catalyzed dehydrogenative cyclization of methanol as a formaldehyde surrogate with a variety of dinucleophiles for facile synthesis of N-heterocycles.The in situ generated formaldehyde via catalytic methanol dehydrogenation can be selectively trapped by diverse dinucleophiles to avoid several possible side reactions.The utilty of this transformation is further highlighted by its successful appliation to the synthesis of 13C-labeled N-heterocycles using 13CH_(3)OH as a readily accessible 13C-isotope reagent.
基金
This project was supported by the National Natural Science Foundation of China(Nos.91845107 and 21822106)
the Foundation of the Department of Education of Guangdong Province(2018KZDXM070 and 2021KTSCX140)。
