摘要
目的 探讨多囊卵巢综合征患者血清血管内皮生长因子、骨钙素水平与胰岛素抵抗及卵巢间质血流参数的关系。方法 将100例多囊卵巢综合征患者设为多囊卵巢综合征组,100例生理周期正常的志愿者妇女设为对照组。将多囊卵巢综合征组中胰岛素抵抗指数≥2.69的46例患者设为胰岛素抵抗组,胰岛素抵抗指数<2.69的54例患者设为非胰岛素抵抗组。比较两组的血清血管内皮生长因子、骨钙素、卵巢间质血流阻力指数、博动指数、胰岛素抵抗指数、生殖激素水平。结果 多囊卵巢综合征组与对照组血清雌二醇、孕激素、泌乳素、促卵泡刺激素水平比较差异无统计学意义(P>0.05);多囊卵巢综合征组血清黄体生成素水平显著高于对照组(P<0.01)。多囊卵巢综合征组血管内皮生长因子水平、胰岛素抵抗指数均显著高于对照组(P<0.01),骨钙素水平、卵巢间质血流阻力指数、博动指数均显著低于对照组(P<0.01)。胰岛素抵抗组血清血管内皮生长因子水平显著高于非胰岛素抵抗组(P<0.01),骨钙素水平、卵巢间质血流阻力指数、博动指数均显著低于非胰岛素抵抗组(P<0.01)。多囊卵巢综合征患者血清血管内皮生长因子水平与胰岛素抵抗指数呈显著正相关(P<0.01),与卵巢间质血流阻力指数、博动指数呈显著负相关(P<0.01);多囊卵巢综合征患者骨钙素水平与胰岛素抵抗指数无明显的相关性(P>0.05),与卵巢间质血流阻力指数、博动指数呈显著正相关(P<0.01)。结论 多囊卵巢综合征患者血清血管内皮生长因子、骨钙素水平与卵巢间质血流变化有明显的相关性,血清血管内皮生长因子水平与患者胰岛素抵抗有关。
Objective To investigate the relationship between serum vascular endothelial growth factor(VEGF),osteocalcin(OC)levels and insulin resistance(IR)and ovarian interstitial blood flow parameters in patients with polycystic ovary syndrome(PCOS).Methods One hundred patients with PCOS were set as the PCOS group,and 100 volunteers with normal physiological cycle were set as the control group.In the PCOS group,46 patients with homeostasis model assessment-IR(HOMA-IR)≥2.69 were set as the HOMA-IR group,and 54 patients with HOMA-IR<2.69 were set as the HOMA-NIR group.The levels of serum VEGF,OC,ovarian interstitial blood flow resistance index,pulsatility index(PI),HOMA-IR and reproductive hormone were compared between the two groups.Results There was no significant difference in the levels of serum estradiol(E2),progesterone(P),prolactin(PRL)and follicle stimulating hormone(FSH)between PCOS group and control group(P>0.05).The level of serum luteinizing hormone(LH)in PCOS group was significantly higher than that in control group(P<0.01).The levels of VEGF and HOMA-IR in PCOS group were significantly higher than those in control group(P<0.01),and the levels of OC, ovarian interstitial blood flow resistance index and PI were significantly lower than those in control group( P <0.01). The serumVEGF level of HOMA-IR group was significantly higher than that of HOMA-NIR group ( P <0.01). The levels of OC, ovarian interstitial blood flow resistance index and PI were significantly lower than those of HOMA-NIR group ( P <0.01). Serum VEGF in PCOS patients was significantly positively correlated with HOMA-IR ( P <0.01), and significantly negatively correlated with ovarian interstitial blood flow parameters and PI ( P <0.01). OC in PCOS patients had no significant correlation with HOMA-IR ( P >0 .05), but was significantly positively correlated with ovarian interstitial blood flow resistance index and PI ( P <0.01). Conclusions Serum VEGF and OC levels in PCOS patients are significantly correlated with changes in ovarian interstitial blood flow, and serum VEGF is associated with IR in patients.
作者
张秀娟
赵艳
姚志芹
Zhang Xiujuan;Zhao Yan;Yao Zhiqin(Puyang Oilfield General Hospital,Puyang 457600,Henan,China)
出处
《临床心身疾病杂志》
CAS
2022年第5期22-25,共4页
Journal of Clinical Psychosomatic Diseases
基金
河南省医学科技攻关计划项目(编号2018032129)。
