摘要
目的:观察平动汤加减联合经颅直流电刺激(tDCS)治疗小儿注意缺陷多动障碍(ADHD)的临床疗效及对神经递质、注意力、反应抑制力的影响。方法:选取ADHD儿童92例,按随机数字表法分为试验组及对照组各46例。对照组给予tDCS治疗,试验组在对照组基础上加用平动汤加减治疗。比较2组临床疗效及治疗前后中医证候积分、多动指数、注意力、反应抑制力及神经递质水平。结果:治疗后,试验组总有效率为91.30%,高于对照组76.09%(P<0.05)。治疗后,2组中医证候积分、多动指数评分、错误数、漏报数均较治疗前降低(P<0.05),反应时间缩短(P<0.05),且试验组上述指标改善优于对照组(P<0.05)。治疗后,2组颜色干扰时间及字义干扰时间均较治疗前缩短(P<0.05),且试验组上述指标均短于对照组(P<0.05)。治疗后,2组血清去甲肾上腺素(NE)、5-羟色胺(5-HT)、多巴胺(DA)水平均较治疗前升高(P<0.05),且试验组神经递质水平高于对照组(P<0.05)。结论:平动汤加减联合tDCS治疗ADHD疗效确切,能提高患儿神经递质水平,改善患者注意力及反应抑制力。
Objective:To observe the clinical effect of modified Pingdong tang combined with transcranial direct current stimulation(tDCS)for attention-deficit/hyperactivity disorder(ADHD)in children and its effect on neurotransmitter,attention and response inhibition.Methods:A total of 92 cases of ADHD children were selected and divided into the experiment group and the control group according to the random number table method,with 46 cases in each group.The control group was treated with tDCS,and the experiment group was additionally treated with modified Pingdong tang based on the treatment of the control group.The Chinese medicine syndrome scores,hyperactivity indexes,attention,response inhibition and neurotransmitter levels before and after treatment and the clinical effects in the two groups were compared.Results:After treatment,the total effective rate was 91.30%in the experiment group,higher than that of 76.09%in the control group(P<0.05).After treatment,the Chinese medicine syndrome scores,hyperactivity indexes,error numbers and underreported numbers in the two groups were decreased when compared with those before treatment(P<0.05),and the reaction time was shortened(P<0.05);the improvement in the above indexes in the experiment group was better than that in the control group(P<0.05).After treatment,the color interference time and word interference time in the two groups were shortened when compared with those before treatment(P<0.05),and the above two indexes in the experiment group were shorter than those in the control group(P<0.05).After treatment,the levels of norepinephrine(NE),5-hydroxytryptamine(5-HT)and dopamine(DA)in serum in the two groups were increased when compared with those before treatment(P<0.05),and the neurotransmitter levels in the experiment group were higher than those in the control group(P<0.05).Conclusion:Modified Pingdong tang combined with tDCS has a definite curative effect in treating ADHD children,which can improve neurotransmitter levels,attention and response inhibition.
作者
万鸽
李孟
张靖
邢栋
WAN Ge;LI Meng;ZHANG Jing;XING Dong
出处
《新中医》
CAS
2022年第15期123-127,共5页
New Chinese Medicine
基金
河南省医学科技攻关计划项目(LHGJ20191453)。
关键词
小儿注意缺陷多动障碍
经颅直流电刺激
平动汤
反应抑制力
5-羟色胺
Attention-deficit/hyperactivity disorder in clildren
Transcranial direct current stimulation
Pingdong tang
Response inhibition
5-hydroxytryptamine
