摘要
目的:观察天钩石膝汤联合常规西药治疗缺血性脑卒中的疗效及对血清指标的影响。方法:选取200例缺血性脑卒中患者为研究对象,按随机数字表法分为对照组和观察组各100例。2组入院后均接受对症治疗,对照组给予依达拉奉注射液静脉滴注,观察组在对照组基础上给予天钩石膝汤加减治疗。比较2组治疗前后美国国立卫生研究院卒中量表(NIHSS)评分及Barthel指数(BI)评分,检测外周血调节性T细胞(Treg)、辅助性T细胞17(Th17)、Th17/Treg、血管内皮生长因子(VEGF)、血管生成素-2(Ang-2)水平。结果:观察组总有效率为95.00%,高于对照组71.00%,差异有统计学意义(P<0.05)。治疗前,2组NIHSS评分、BI评分比较,差异无统计学意义(P>0.05)。治疗后,2组NIHSS评分较治疗前降低,BI评分较治疗前升高(P<0.05);观察组NIHSS评分低于对照组,BI评分高于对照组(P<0.05)。治疗前,2组Treg、Th17、Th17/Treg水平比较,差异无统计学意义(P>0.05)。治疗后,2组Treg水平较治疗前升高,Th17及Th17/Treg水平较治疗前降低(P<0.05);且观察组Treg水平高于对照组,Th17及Th17/Treg水平低于对照组(P<0.05)。治疗前,2组VEGF、Ang-2水平比较,差异无统计学意义(P>0.05)。治疗后,2组VEGF、Ang-2水平较治疗前升高(P<0.05),且观察组VEGF、Ang-2水平高于对照组(P<0.05)。结论:天钩石膝汤联合常规西药治疗缺血性脑卒中的疗效较好,可有效改善患者神经功能及日常活动能力,其机制可能与调节Th17/Treg、VEGF及Ang-1水平有关。
Objective:To observe the curative effect of Tiangou Shixi tang combined with routine western medicine for ischemic stroke and its effects on serum indexes.Methods:A total of 200 cases of patients with ischemic stroke were selected as the study objects and divided into the control group and the observation group according to the random number table method,with 100 cases in each group.Both groups were given symptomatic treatment after admission;the control group was given intravenous drip with edaravone injection,and the observation group was additionally treated with modified Tiangou Shixi tang based on the treatment of the control group.The scores of National Institutes of Health Stroke Scale(NIHSS)and Barthel Index(BI)were compared between the two groups before and after treatment,and the levels of regulatory T cells(Treg),helper T cells 17(Th17),Th17/Treg,vascular endothelial growth factor(VEGF)and angiopoietin-2(Ang-2)in peripheral blood were detected.Results:The total effective rate was 95.00%in the observation group,higher than that of 71.00%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of scores of NIHSS and BI between the two groups(P>0.05).After treatment,NIHSS scores in the two groups were decreased when compared with those before treatment,and BI scores were increased(P<0.05);NIHSS score in the observation group was lower than that in the control group,and BI score was higher(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of Treg,Th17 and Th17/Treg between the two groups(P>0.05).After treatment,Treg levels in the two groups were increased when compared with those before treatment,and levels of Th17 and Th17/Treg were decreased(P<0.05);Treg level in the observation group was higher than that in the control group,and levels of Th17 and Th17/Treg were lower(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of VEGF and Ang-2 between the two groups(P>0.05).After treatment,levels of VEGF and Ang-2 in the two groups were increased when compared with those before treatment(P<0.05),and the two levels in the observation group were higher than those in the control group(P<0.05).Conclusion:Tiangou Shixi tang combined with routine western medicine has an ideal curative effect in the treatment of ischemic stroke.It can effectively improve the neurological function and daily activity of patients,and its mechanism may be related to the regulation of levels of Th17/Treg,VEGF and Ang-1.
作者
杨娜
张铭
YANG Na;ZHANG Ming
出处
《新中医》
CAS
2022年第15期71-74,共4页
New Chinese Medicine
