摘要
目的:探讨裸花紫珠颗粒治疗慢性阻塞性肺疾病(COPD)急性加重期患者的临床效果及对患者血清炎症因子的影响。方法:收集2020年1月—2021年10月诊治的慢性阻塞性肺疾病急性加重期患者50例,采用信封随机化分组法分为对照组和观察组,每组25例。对照组行常规治疗,观察组在对照组基础上加用裸花紫珠颗粒治疗。比较两组临床治疗总有效率、不良反应发生率及治疗前后肺功能、血清炎症因子水平。结果:两组治疗前肺功能、血清炎症因子水平比较,差异无统计学意义(P>0.05)。观察组临床治疗总有效率与治疗后各项肺功能指标均高于对照组,且治疗后血清炎症因子[C反应蛋白(CRP)、降钙素原(PCT)、白介素-6(IL-6)]水平低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P<0.05)。结论:裸花紫珠颗粒治疗COPD急性加重期患者的临床效果显著,有利于改善患者血清炎症因子和提高机体肺功能,且安全性好。
Objective:To investigate the clinical effect of Luohua Zizhu Granules in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease and its effect on serum inflammatory factors.Methods:A total of 50 patients with acute exacerbation of chronic obstructive pulmonary disease(COPD)who were diagnosed and treated in our hospital from January 2020 to October 2021 were collected.Using the envelope randomization method,the patients were divided into the control group and the observation group,25 cases in each group.The control group received routine treatment,and the observation group was additionally treated with Luohua Zizhu Granules based on the control group.The total effective rate of clinical treatment,incidence of adverse reactions,pulmonary function and serum inflammatory factor indexes before and after treatment were compared in different groups.Results:There was no significant difference in the incidence of adverse reactions,lung function and serum inflammatory factors between the observation group and the control group before treatment(P>0.05).The total effective rate of clinical treatment and various pulmonary function indexes in the observation group were higher than those in the control group,and serum inflammatory factors[C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6)after treatment]was lower than the control group,and the data were statistically different(P<0.05).Conclusion:Luohua Zizhu Granules has a significant clinical effect in the treatment of patients with acute exacerbation of COPD,which is beneficial to improve the serum inflammatory factors and the lung function of the patients,and its application is safe.
作者
谢小金
裴丽俊
XIE Xiaojin;PEI Lijun(The Fifth People's Hospital of Ganzhou City,Ganzhou 341000,China;The Third People's Hospital of Ganzhou City,Ganzhou 341000,China)
出处
《临床医药实践》
2022年第9期643-645,共3页
Proceeding of Clinical Medicine
基金
江西省中医药管理局科技计划项目(项目编号:2021B485)。
关键词
裸花紫珠颗粒
慢性阻塞性肺疾病
急性加重期
临床效果
血清炎症因子
Luohua Zizhu Granule
chronic obstructive pulmonary disease
acute exacerbation
clinical effect
serum inflammatory factors
