摘要
《"健康中国2030"规划纲要》强调积极推动主动健康以应对人口老龄化挑战,对个体与群体层面的抗衰老预防控制策略提出更高要求。衰老受遗传因素和环境暴露的共同影响。近20年来,随着高通量遗传检测技术和相关算法的发展,以及高质量大规模人群基因组研究的开展,极大促进了对衰老遗传学的研究。本文旨在对衰老相关的全基因组关联研究展开概述。
"Active health"has been emphasized in"Healthy China 2030"in dealing with the challenges of population aging,so the anti-aging strategies are requires to be more precise and effective at both individual and population levels.Aging is influenced by both genetic and environmental factors.In the recent 20 years,the research of genetics of human ageing has been greatly facilitated owning to the development of high-throughput sequencing techniques,statistical methodology for multi-omics data,as well as the growing qualified evidence of large-scale population-based genomic research.This paper provides a review of genome-wide association research of aging.
作者
王月清
肖梦
杨海铭
宋明钰
赵禹碹
庞元捷
高文静
曹卫华
黄涛
余灿清
吕筠
李立明
孙点剑一
Wang Yueqing;Xiao Meng;Yang Haiming;Song Mingyu;Zhao Yuxuan;Pang Yuanjie;Gao Wenjing;Cao Weihua;Huang Tao;Yu Canqing;Lyu Jun;Li Liming;Sun Dianjianyi(Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100191,China;Peking University Center for Public Health and Epidemic Preparedness&Response,Beijing 100191,China)
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2022年第8期1338-1342,共5页
Chinese Journal of Epidemiology
基金
国家自然科学基金(81941018,82103920)
国家重点研发计划(2020YFC2003405)。
关键词
衰老
全基因组关联研究
单核苷酸多态性
Aging
Genome-wide association study
Single nucleotide polymorphism
