摘要
目的:系统评价重症病人再喂养综合征与预后的关系。方法:计算机检索PubMed、the Cochrane Library、EMbase、Web of Science、中国知网、万方数据库、中国生物医学文献数据库中有关重症病人再喂养综合征对病人预后影响的队列研究,检索时限为建库至2021年6月20日。经质量评价后,采用RevMan 5.4软件进行Meta分析。结果:共纳入11项研究,涉及2765例研究对象。Meta分析结果显示,与未发生再喂养综合征的病人相比,发生再喂养综合征的病人6个月死亡风险显著增加[OR=1.50,95%CI(1.14,1.96),P=0.003]、重症监护室(ICU)住院时间显著延长[SMD=0.32,95%CI(0.14,0.51),P<0.001]。结论:现有证据表明,重症病人发生再喂养综合征会增加6个月死亡风险、延长ICU住院时间;但受研究数量和异质性的影响,其与短期死亡风险和机械通气时间的关系尚无法得出定论。临床应重视对再喂养综合征的监测和防控,未来研究应尽快规范再喂养综合征的定义,进行多中心、大样本的高质量研究以充实相关证据。
Objective:To systematically evaluate the relationship between refeeding syndrome and prognosis of critically ill patients.Methods:We searched PubMed,the Cochrane Library,EMbase,Web of Science,CNKI,Wanfang,SinoMed databases for Cohort studies on the relationship between refeeding syndrome and prognosis of critically ill patients.The search time was from the establishment of databases to 20 June,2021.Results:A total of 11 publications including 2765 patients were included.The meta-analysis showed that refeeding syndrome increased the six-month mortality[OR=1.50,95%Cl(1.14,1.96),P=0.003],prolonged the length of ICU stay[SMD=0.32,95%Cl(0.14,0.51),P<0.001].Conclusions:Existing evidence showed that refeeding syndrome increased the risk of six-month death and the length of ICU stay,but the relationship between refeeding syndrome and short-term mortality and the length of mechanical ventilation hadn′t been clear.Clinical staff should pay more attention to the refeeding syndrome.In the future,it′s necessary to specify the definition of refeeding syndrome,high quality studies with standardized definition will be important to explore the effect of refeeding syndrome in the prognosis of critically ill patients deeply.
作者
马慧颖
绳宇
朱信雨
张培宇
张修齐
褚晓妍
MA Huiying;SHENG Yu;ZHU Xinyu;ZHANG Peiyu;ZHANG Xiuqi;CHU Xiaoyan(School of Nursing,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100144 China)
出处
《护理研究》
北大核心
2022年第17期3023-3031,共9页
Chinese Nursing Research
关键词
再喂养综合征
重症监护室
死亡风险
机械通气时间
预后
META分析
refeeding syndrome
intensive care unit
ICU
risk of death
mechanical ventilation time
prognosis
Meta analysis
