摘要
目的探究输尿管结石并发感染患者血清高迁移率族蛋白B1(HMGB1)、半胱氨酸天冬氨酸蛋白酶9(Caspase9)、白细胞介素-10(IL-10)水平变化意义。方法选取河北医科大学第一医院泌尿外科2019年1月至2022年1月收治的108例输尿管结石并发感染患者作为观察组,另选取同期50例单纯输尿管结石未并发感染患者作为对照组。比较两组血清HMGB1、Caspase9、IL-10水平;以观察组与对照组血清HMGB1、Caspase9、IL-10水平平均值为界分为低水平与高水平患者,分析血清HMGB1、Caspase9、IL-10水平对输尿管结石患者并发感染危险度的影响;根据患者住院期间是否发生尿源性脓毒症分组,比较发生与未发生尿源性脓毒症患者术前、术后1 d、7 d血清HMGB1、Caspase9、IL-10水平;并评价血清HMGB1、Caspase9、IL-10对输尿管结石并发感染患者尿源性脓毒症的预测价值。结果观察组血清HMGB1、Caspase9、IL-10水平较对照组高,差异均有统计学意义(P<0.05)。血清HMGB1、Caspase9、IL-10高水平者并发感染风险是低水平者的4.124倍、3.277倍、4.001倍(P<0.05)。术后7 d,发生尿源性脓毒症患者血清HMGB1、Caspase9、IL-10水平较未发生患者高,差异均有统计学意义(P<0.05)。绘制术后7 d血清HMGB1、Caspase9、IL-10水平预测输尿管结石并发感染患者预后的ROC曲线,各指标联合预测AUC为0.916,较单独预测价值更大(P<0.05)。结论输尿管结石并发感染患者血清HMGB1、Caspase9、IL-10水平升高,且随感染加剧、病情恶化其水平呈渐进性升高趋势,临床检测其水平,有助于预测感染及尿源性脓毒症风险,为临床工作提供依据。
Objective To investigate the significance of changes in serum high mobility group protein B1(HMGB1),cysteine aspartate protease 9(Caspase9),and interleukin-10(IL-10)levels in patients with ureteral calculi complicated by infection.Methods One hundred and eight patients with ureteral stones complicated by infection admitted to the Department of Urology,First Hospital of Hebei Medical University from January 2019 to January 2022 were selected as the observation group,and another 50 patients with simple ureteral stones uncomplicated by infection in the same period were selected as the control group.The changes of serum HMGB1,caspase9 and IL-10 levels in the two groups were detected and analyzed.Results Serum HMGB1,caspase9,and IL-10 levels in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The risk of concurrent infection in patients with high levels of serum HMGB1,caspase9,and IL-10 was 4.124 times,3.277 times,and 4.001 times that of those with low levels(P<0.05).On the 7th day after operation,the levels of serum HMGB1,Caspase9 and IL-10 in patients with urosepsis were higher than those in patients without,and the differences were statistically significant(P<0.05).The ROC curves of serum HMGB1,caspase9,and IL-10 levels at 7 days after surgery were drawn to predict the prognosis of patients with ureteral stones complicated by infection.The combined prediction AUC of each indicator was 0.916,which was more valuable than individual prediction(P<0.05).Conclusion Serum HMGB1,caspase9,and IL-10 levels are elevated in patients with ureteral stones complicated by infection,and their levels increased gradually with the aggravation of infection and disease progression.Clinical detection of their levels is helpful for predicting infection and urinary sepsis risk,and provide a basis for clinical work.
作者
罗子靖
王磊
高景宇
徐哲
任凌云
王照
LUO Zijing;WANG Lei;GAO Jingyu;XU Zhe;REN Lingyun;WANG Zhao(Department of Urology,the First Hospital of Hebei Medical University,Shijiazhuang,Hebei,China,050031)
出处
《分子诊断与治疗杂志》
2022年第8期1385-1388,1393,共5页
Journal of Molecular Diagnostics and Therapy
基金
河北省卫生健康委科研基金项目(20160204)。
