摘要
目的分析老年急性胆囊炎患者血清高敏C反应蛋白(hs-CRP)、白细胞介素-15(IL-15)与幽门螺杆菌(Hp)感染的关系及其对急性胆囊炎Hp感染的预测价值。方法分析2017年4月至2019年5月浙江省人民医院收治的100例老年急性胆囊炎患者的临床资料。依据Hp感染情况分为感染组与非感染组。比较两组血清hs-CRP、IL-15水平;观察胆囊黏膜胃上皮化生情况;分析hs-CRP、IL-15、Hp阳性率的相关性及hs-CRP、IL-15预测老年急性胆囊炎Hp感染的效能。结果53例老年急性胆囊炎患者感染Hp。感染组血清hs-CRP、IL-15水平均高于非感染组(P<0.05)。感染组胆囊黏膜胃上皮化生率高于非感染组(P<0.05)。Hp阳性率与hs-CRP、IL-15呈正相关(r=0.694、0.677,P<0.05);hs-CRP与IL-15呈正相关(r=0.686,P<0.05)。hs-CRP、IL-15联合预测急性胆囊炎Hp感染时曲线下面积为0.870,灵敏度、特异度分别为75.47%、95.74%。结论老年急性胆囊炎Hp感染可加重胆囊炎局部炎症反应,诱导hs-CRP、IL-15释放;hs-CRP、IL-15与Hp感染相关性较高,可作为急性胆囊炎早期Hp感染初筛的依据。
Objective To analyze the relationship between serum high-sensitivity C-reactive protein(hs-CRP),interleukin-15(IL-15),and Helicobacter pylori(Hp)infection in elderly patietns with acute cholecystitis,and their value in predicting Hp infection.Methods The clinical data of 100 elderly patients with acute cholecystitis admitted to Zhejiang Provincial People’s Hospital from April 2017 to May 2019 were analyzed.According to Hp infection,they were divided into infected group and non-infected group.Serum hs-CRP and IL-15 levels were compared between two groups;the metaplasia of gallbladder mucosa and gastric epithelium was observed;the correlation of hs-CRP,IL-15,and Hp positive rate and the efficacy of hs-CRP and IL-15 in predicting Hp infection in elderly patients with acute cholecystitis were analyzed.Results Fifty-three elderly patients with acute cholecystitis were infected with Hp.Serum hs-CRP and IL-15 levels in infected group were higher than those in non-infected group(P<0.05).The metaplasia rate of gallbladder mucosa and gastric epithelium in infected group was higher than that in non-infected group(P<0.05).Hp positive rate was positively correlated with hs-CRP and IL-15(r=0.694,0.677,P<0.05);there was positive correlation between hs-CRP and IL-15(r=0.686,P<0.05).When hs-CRP and IL-15 were combined to predict Hp infection in acute cholecystitis,the area under the curve was 0.870,the sensitivity and specificity were 75.47%and 95.74%,respectively.Conclusion Hp infection in elderly patients with acute cholecystitis can aggravate the local inflammatory response of cholecystitis,and induce release of hs-CRP and IL-15;hs-CRP and IL-15 are highly correlated with Hp infection,which can be used as a basis for preliminary screening of early Hp infection.
作者
蔡柳燕
季茜茜
李恒杰
CAI Liuyan;JI Qianqian;LI Hengjie(Emergency Intensive Care Center,Zhejiang Provincial People’s Hospital People’s Hospital of Hangzhou Medical College,Zhejiang Province,Hangzhou 310000,China)
出处
《中国医药导报》
CAS
2022年第23期9-12,共4页
China Medical Herald
基金
浙江省医药卫生科技计划项目(2020KY028)
浙江省中医药科技计划项目(2020ZB012)。
关键词
急性胆囊炎
幽门螺杆菌
高敏C反应蛋白
白细胞介素-15
感染
Acute cholecystitis
Helicobacter pylori
High-sensitivity C-reactive protein
Interleukin-15
Infection
