摘要
近些年来,人体的共生微生物群对人类健康和疾病的研究逐渐成为热点。特别是人类微生物组计划和16S rRNA基因测序技术的出现,进一步促进了与人类相关微生物群的研究。肠道微生物群是人体最庞大的微生态系统。一方面,正常条件下,肠道微生物群在维持宿主免疫平衡,促进营养物质代谢和维持肠道稳态中起到重要作用。另一方面,越来越多的证据显示肠道微生物群失调与多种疾病有关,除影响肠道健康外,还影响肠外多种组织、器官。随着肠道微生物群与大脑之间相互作用的"肠-脑轴"概念出现后,研究者提出肠道微生物群与眼之间可能同样有"肠-眼轴"的存在。本文就近年来关于肠道微生物群在眼科疾病,包括角膜病、葡萄膜炎、视网膜病,以及与系统性疾病相关眼病中的作用进行综述,以期为肠-眼轴的存在提供证据,并为未来眼科疾病的治疗提供新思路。
In recent years,the study of symbiotic microbial community on human health and disease has gradually become a hot spot.In particular,the Human Microbiome Project and the emergence of 16S rRNA gene sequencing technology have further promoted the study of human-related microbiota.The gut microbiota is the largest microecosystem of the human body.Normal gut microbiota plays an important role in maintaining host immune balance,promoting nutrient metabolism and sustaining intestinal homeostasis.At present,there is increasing evidence that gut microbiota disorders are associated with a variety of diseases,not only having an impact on the intestinal tract but also affecting many extraintestinal tissues and organs.With the emergence of the concept of gut-brain axis,which interacts between gut microbiota and brain,some researchers suggest that there may also be gut-eye axis between gut microbiota and eye.This review summarized the recent research advances on the role of gut microbiota in ophthalmic diseases,including corneal diseases,uveitis,retinopathies,and the ophthalmic diseases associated with systemic diseases,in the hope that it could provide evidence for the existence of gut-eye axis and new idea for the treatment of ophthalmic diseases in the future.
作者
耿超(综述)
李亚红
张琰(审校)
Geng Chao;Li Yahong;Zhang Yan(Tianjin Key Laboratory of Retinal Functions and Diseases,Tianjin Branch of National Clinical Research Center for Ocular Disease,Eye Institute and School of Optometry,Tianjin Medical University Eye Hospital,Tianjin 300384,China)
出处
《中华实验眼科杂志》
CAS
CSCD
北大核心
2022年第8期785-790,共6页
Chinese Journal Of Experimental Ophthalmology
基金
国家自然科学基金项目(81970827)
天津市自然科学基金重点项目(17JCZDJC35600)
2017年天津市高校"中青年骨干创新人才培养计划"项目
天津医科大学眼科医院高水平创新型人才计划——杰出学者/中年领军人才项目(YDYYRCXM-B2018-02)。
关键词
肠道微生物群/生理
眼科疾病
固有免疫反应
肠-眼轴
Gastrointestinal microbiome/physiology
Ophthalmic disease
Immunity,innate
Gut-eye axis
