摘要
慢性阻塞性肺疾病患者不单出现肺部症状及炎症, 往往也可合并其他慢性疾病, 产生全身炎症反应, 引起显著的全身效应, 并可出现肌肉萎缩。本文主要综合了近年来国内外有关慢性阻塞性肺疾病患者的体成分变化相关研究, 以骨骼肌质量指数为主要研究指标, 对骨骼肌质量指数的概念进行了进一步分析, 并对骨骼肌质量指数的评估方法进行了综述与对比。随后寻找该指标与其他慢病及合并症(慢性炎症、肌少症、骨质疏松等)的联系, 同时对骨骼肌质量指数在临床中的使用进行了总结, 提出今后骨骼肌质量指数在临床中进一步使用的方向。
Patients with chronic obstructive pulmonary disease(COPD)not only present respiratory symptoms and pulmonary inflammation,but also are complicated with other chronic diseases,resulting in systemic inflammatory response,significant systemic effects,and muscle atrophy.In this paper,we reviewd the recent studies on body composition of COPD patients at home and abroad.Skeletal muscle mass index(SMI)is regarded as the main study index.The concept of SMI was further analyzed,and the evaluation methods of SMI were reviewed and compared.Its relationships with other chronic diseases and comorbidities(chronic inflammation,sarcopenia,osteoporosis,etc.)were explored.The use of SMI in clinical practice was summarized and the future application of SMI in clinical setting was put forward.
作者
何佳泽
杨汀
He Jiaze;Yang Ting(Capital Medical University,Beijing 100069,China;Department of Pulmonary and Critical Care Medicine,Center of Respiratory Medicine,China-Japan Friendship Hospital,National Center for Respiratory Medicine,Institute of Respiratory Medicine,Chinese Academy of Medical Sciences,National Clinical Research Center for Respiratory Diseases,WHO Collaborating Centre for Tobacco Cessation and Respiratory Diseases Prevention,Beijing 100029,China)
出处
《国际呼吸杂志》
2022年第14期1097-1102,共6页
International Journal of Respiration
基金
中国医学科学院医学与健康科技创新工程重大协同创新项目(2021-I2M-1-049)。
关键词
肺疾病
慢性阻塞性
骨质疏松
预后
骨骼肌质量指数
肌少症
Pulmonary disease,chronic obstructive
Osteoporosis
Prognosis
Skeletal muscle mass index
Sarcopenia
