摘要
脊柱融合重建手术对生物材料有巨大的需求,而现有的脊柱融合材料无论从成骨活性、骨传导性以及骨诱导性方面,距离“金标准”材料——自体骨仍有明显的差距。本文主要从脊柱融合术中填充植骨材料、骨诱导材料以及支撑重建材料三个方面,对目前临床普遍应用的不同脊柱融合材料的研发历史和应用现状做一述评,分析其现存的问题和缺陷,期望随着材料学的不断发展进步,能进一步推动脊柱融合材料的革新,提高脊柱融合手术整体疗效。
Biomaterials are needed for spinal fusion reconstruction.However,there is still a great gap in terms of osteogenic activity,osteoconduction and osteoinduction between the present spinal fusion materials and autograft bone,which is the“gold standard”materials.The article was expound from three different aspects:the unstructured materials,osteoinduction materials and structured reconstruction materials.We reviewed the research history and application status of different spinal fusion materials that widely used in clinical,analyzed the problems and flaws,and then pointed the direction of future development.We hope the spinal fusion materials will being improved along with the progress in material science,and finally improving the clinical effect of spinal fusion.
作者
宋跃明
杨曦
SONG Yueming;YANG Xi(Department of Orthopedics,Orthopedic Research Institute,West China Hospital,Sichuan University,Chengdu 610041,China)
出处
《西部医学》
2022年第8期1093-1096,共4页
Medical Journal of West China
基金
四川大学华西医院人才卓越发展项目(ZYGD21001)。
关键词
脊柱融合
生物材料
人工骨
椎间融合器
Spinal fusion
Biomaterials
Artificial bone
Interbody cage
