摘要
目的:分析乳腺癌患者部分外周血指标的变化及血清糖类抗原125(CA125)、糖类抗原153(CA153)和癌胚抗原(CEA)检测的诊断价值。方法:将2018年1月-2021年8月北京市健宫医院收治的经病理检查确诊为乳腺癌的102例患者作为恶性组(其中65例发生淋巴结转移作为转移组,37例无淋巴结转移作为未转移组),53例乳腺良性肿瘤患者作为良性组,另取同期于北京市健宫医院体检的48例健康人员作为对照组。检测各组外周血淋巴细胞计数(LYM)、中性粒细胞计数(NEU)、NEU与LYM的比值(NLR)、红细胞体积分布宽度(RDW)、前白蛋白和唾液酸水平,以及血清CA125、CA153和CEA水平。以病理检查结果为金标准,分析单项及联合检测对乳腺癌的诊断效能。结果:各组LYM、NLR、RDW、前白蛋白和唾液酸比较,差异均有统计学意义(P<0.05);各组NEU比较,差异无统计学意义(P>0.05)。三组血清CA125、CA153和CEA水平比较,差异均有统计学意义(P<0.05)。CA125、CA153、CEA联合检测敏感度、准确度均高于各项指标单独检测(P<0.05)。结论:外周血LYM、NLR、RDW等指标对乳腺癌的早期诊断及是否发生转移有重要参考价值。血清CA125、CA153、CEA检测对乳腺癌均有一定诊断价值,三项联合检测能进一步提高诊断效能,临床价值更高。
Objective:To analyze the changes of peripheral blood indexes and the diagnostic value of serum carbohydrate antigen 125(CA125),carbohydrate antigen 153(CA153)and carcinoembryonic antigen(CEA)in patients with breast cancer.Method:A total of 102 cases with breast cancer diagnosed by pathology in Beijing Jiangong Hospital from January 2018 to August 2021 were selected as the malignant group(65 cases of lymph node metastasis was as the metastasis group,37 cases without lymph node metastasis was as the non metastasis group),53 cases of benign breast tumor was as the benign group,and 48 healthy persons who received physical examination in the same period was as control group.The peripheral blood lymphocyte count(LYM),neutrophil count(NEU),ratio of neu to lym(NLR),erythrocyte volume distribution width(RDW),prealbumin and sialic acid levels,as well as the levels of serum CA125,CA153 and CEA were measured.The diagnostic efficiency of single and combined tests for breast cancer was analyzed by pathological examination.Result:There were significant differences in LYM,NLR,RDW,prealbumin and sialic acid among groups(P<0.05),and there was no significant difference in NEU among groups(P>0.05).There were significant differences in serum CA125,CA153 and CEA levels among three groups(P<0.05).The sensitivity and accuracy of CA125,CA153 and CEA combined detection were higher than those of each index alone(P<0.05).Conclusion:Peripheral blood LYM,NLR,RDW and other indicators have important reference value for early diagnosis and metastasis of breast cancer.The detection of serum CA125,CA153 and CEA has certain diagnostic value for breast cancer.The three combined tests can further improve the diagnostic efficiency and clinical value.
作者
徐萌
绳波
崔红权
XU Meng;SHENG Bo;CUI Hongquan(Beijing Jiangong Hospital,Beijing 100054,China;不详)
出处
《中外医学研究》
2022年第21期66-70,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
