摘要
目的探讨维持性血液透析(hemodialysis,HD)患者长期使用质子泵抑制剂(proton pump inhibitor,PPI)与感染的相关性。方法收集浙江省温州市人民医院2014年1月至2021年12月行维持性血液透析治疗的174例患者,根据有无使用质子泵抑制剂分为研究组(使用PPI)和对照组(未使用PPI),每组各87例,比较两组患者各项实验室指标及感染的发生率,及研究组使用PPI治疗前后各项指标的变化,并应用多因素Logistic回归分析验证PPI与感染的相关性。结果使用质子泵抑制剂组较未使用组感染发生率高,粒细胞降低(P<0.05)。多因素回归分析显示质子泵抑制剂是维持性血液透析患者发生感染的独立危险因素(P<0.05)。结论长期使用质子泵抑制剂能增加血液透析患者的感染风险,影响患者预后,长期用药前应权衡利弊。
Objective To investigate the correlation between long-term use of proton pump inhibitor(PPI)and infection in maintenance hemodialysis(HD)patients.Methods A total of 174 patients who underwent maintenance hemodialysis in our hospital from January 2014 to December 2021 were collected and divided into study group(used PPI)and control group(not used PPI)according to the use of proton pump inhibitors,with 87 cases in each group.The laboratory indexes and the incidence of infection in the two groups were compared,as well as the changes of various indexes before and after PPI treatment in the study group.The correlation between PPI and infection was verified by multivariate logistic regression analysis.Results The granulocytes in the proton pump inhibitor group were lower and the incidence of infection was higher than that in the non proton pump inhibitor group(P<0.05).Multivariate regression analysis showed that proton pump inhibitor was an independent risk factor for infection in maintenance hemodialysis patients(P<0.05).Conclusion Long term use of proton pump inhibitors can increase the risk of infection and affect the prognosis of hemodialysis patients.The advantages and disadvantages should be weighed before long-term use.
作者
杨仲煌
贾李跃
王牡丹
朱源
董芍芍
YANG Zhonghuang;JIA Liyue;WANG Mudan;ZHU Yuan;DONG Shaoshao(Department of Nephrology,Wenzhou People’s Hospital,Wenzhou 325000,China)
出处
《中国现代医生》
2022年第20期51-54,58,共5页
China Modern Doctor
关键词
质子泵抑制剂
维持性血液透析
感染
多因素回归分析
Proton pump inhibitor
Maintenance hemodialysis
Infected
Multivariate regression analysis
