摘要
目的观察和评估经皮耳迷走神经刺激仪治疗高原睡眠障碍的临床疗效。方法采用单盲随机安慰剂对照法,将收集到的高原地区睡眠障碍患者随机分成对照组(n=30)及观察组(n=27),观察组接受经皮耳迷走神经刺激治疗,对照组进行伪刺激干预,均治疗2 w,每周5次,两组治疗前、后分别用匹兹堡睡眠指数量表(PSQI)、贝克抑郁量表(BDI-21)和广泛性焦虑量表(GAD-7)进行评估。结果两组患者治疗前在PSQI、BDI-21和GAD-7评分上无统计学差异(P>0.05);治疗2 w后,观察组患者治疗后PSQI、BDI-21总分均低于对照组(P<0.01),且观察组PSQI及BDI-21评分改善程度高于对照组,但两组治疗前后在GAD-7评分上差异无统计学意义(P>0.05)。结论经皮耳迷走神经刺激能有效改善高原睡眠障碍患者的睡眠质量,降低抑郁水平,但本次试验干预的周期较短,缺少多导睡眠监测指标,仍需后续进行长时程、大样本、多指标试验为临床推广提供依据。
Objective To observe and evaluate the clinical efficacy of transcutaneous auricular vagus nerve stimulation instrument for sleep disorder at high altitude plateau.Methods The patients with high altitude sleep disorder in the group were randomly divided into control group(n=30)and observation group(n=27).The observation group received percutaneous vagal stimulation,and the control group received pseudo stimulation intervention for two weeks,five times a week.Before and after treatment,the two groups were measured with Pittsburgh Sleep Quality Index(PSQI)and Beck Depression Inventory(BDI),Generalized Anxiety Disorder(GAD-7)were evaluated.Results There was no significant difference in PSQI,BDI-21 and GAD-7 scores between the two groups before treatment(P>0.05);After two weeks of treatment,the total scores of PSQI and BDI-21 in the observation group were lower than those in the control group(P<0.01),and the improvement of PSQI and BDI-21 scores in the observation group was higher than that in the control group,but there was no significant difference in GAD-7 scores between the two groups before and after treatment(P>0.05).Conclusion Transcutaneous auricular vagus nerve stimulation can effectively improve the sleep quality of patients with high altitude sleep disorders and reduce the level of depression.However,the intervention cycle of this trial is short and there is a lack of polysomnography indicators.It is still necessary to carry out long-term,large sample and multi-index trials to provide basis for clinical promotion.
作者
张良
蔺华利
陈晨
李逢战
金银川
张钦涛
苑会羚
杨群
ZHANG Liang;LIN Huali;CHEN Chen(School of Public Health,Shanxi University of Traditional Chinese Medicine,Xianyang 712046,China)
出处
《中风与神经疾病杂志》
CAS
2022年第5期434-437,共4页
Journal of Apoplexy and Nervous Diseases
基金
陕西省自然科学基础研究计划重点项目(2021JZ-31)。
关键词
高原
睡眠障碍
迷走神经刺激
疗效
Plateau
Sleep disorder
Vagus nerve stimulation
Efficacy
