摘要
目的 分析肺癌患者医院感染率及病原菌分布特点,及医院感染的相关危险因素,为医院感染防控提供依据.方法 回顾性分析2019年2月至2021年8月405人次肺癌患者的临床资料,62例次经病原学确诊医院感染的患者作为医院感染组,随机匹配同期住院的62例未发生医院感染的肺癌患者作为对照组,采用单因素分析比较两组患者的性别、年龄、住院时间、慢性合并症、肿瘤分期、病理类型、ECOG-PS评分、静脉化疗、深静脉置管、>Ⅲ度骨髓抑制、营养状况等对医院感染的影响,采用多因素Logistic回归分析医院感染发生的独立危险因素.结果 医院感染发生率为15.31%,病原菌以革兰阴性菌感染为主;菌株类型前5位依次为肺炎克雷伯菌、大肠埃希菌、金黄色葡萄球菌、鲍曼不动杆菌以及铜绿假单胞菌;多因素Logistic回归分析提示住院>2周、静脉化疗、营养不良、>III度骨髓抑制以及ECOG-PS评分2~3分是肺癌患者发生医院感染的独立危险因素(P<0.05).结论 肺癌住院患者医院感染率高,以革兰阴性菌感染为主,临床工作中应加强患者医院感染影响因素识别,对高危患者应做好预防措施,减少医院感染的发生.
Objective To investigate the nosocomial infection rate and pathogen distribution characteristics of lung cancer patients in oncology department,and analyze the risk factors of nosocomial infection,so as to provide basis for prevention and control of nosocomial infection.Methods The clinical data of 62 lung cancer patients with nosocomial infection admitted to the Department of oncology of Shaoxing Central Hospital from February 2019 to August 2021 were retrospectively analyzed and matched as the nosocomial infection group,62 lung cancer patients without nosocomial infection in the same period were randomly matched as the control group.Univariate analysis was used to compare variables between the two groups,including gender,age,length of hospital stay,chronic complications,tumor stage,pathological type,ECOG-PS score,intravenous chemotherapy,implants,bone marrow suppression above grade III,and nutritional status.Multivariate logistic regression was used to analyze the independent risk factors of nosocomial infection.Results The incidence of nosocomial infection was 15.31%.Gram-negative bacteria were the main pathogens,the top five strains were KlebsieDa pneumoniae,Escherichia coli,Staphylococcus aureus,Acinetobacter bauniannii and Pseudomonas aeruginosa,multivariate logistic regression analysis showed that hospitalization for more than 2 weeks,intravenous chemotherapy,nutritional risk,niyelosuppression above grade III and ECOG-PS score of 2-3 were independent risk factors for nosocomial infection in lung cancer patients(P<0.05).Conclusion The nosocomial infection rate of lung cancer inpatients is high,the main pathogen is gram-negative bacteria,and preventive measures should be taken for high-risk patients to reduce the incidence of nosocomial infection.
出处
《浙江临床医学》
2022年第5期715-717,共3页
Zhejiang Clinical Medical Journal
关键词
肺癌
医院感染
化疗
病原菌
影响因素
Lung cancer
Nosocomial infection
Chemotherapy
Pathogenic bacteria
Influence factor
