摘要
目的 探讨2型糖尿病(T2DM)患者血清中细胞角蛋白19片段抗原21-1(CYFRA21-1)异常升高的原因。方法 收集164例T2DM患者为患者组,根据CYFRA21-1水平将T2DM患者分为两组,即CYFRA21-1水平正常组(81例)和CYFRA21-1水平升高组(83例)。另以78例健康体检者作为健康组。分别检测CYFRA21-1水平,并收集空腹血糖(FPG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、血清蛋白(ALB)、肌酐(Cr)、尿微量清蛋白(UAlb)、糖尿病病程等数据进行分析。结果 CYFRA21-1、FPG、HbA1c、TG、HDL-C、血ALB、UAlb、体质量指着(BMI)在3组间差异均有统计学意义(P<0.05)。CYFRA21-1水平与FPG、HbA1c、LDL-C、HDL-C、血ALB、Cr、UAlb、病程均有相关性(P<0.05)。多元回归分析显示FPG、HbA1c、HDL-C、LDL-C是CYFRA21-1升高的危险因素(P<0.05)。结论 T2DM患者血清CYFRA21-1升高与多种因素有关,临床上应结合血糖、糖化血红蛋白、血脂水平综合考虑,以免误诊。
Objective To explore the cause of abnormal increase of serum cytokeratin 19 fragment antigen 21-1(CYFRA21-1)in patients with type 2 diabetes(T2DM).Methods One hundred and sixty-four T2DM patients were selected as the patient group.According to the level of CYFRA21-1,T2DM patients were divided into two groups:the normal CYFRA21-1 level group(n=81)and the elevated CYFRA21-1 level group(n=83).In addition,78 healthy people were enrolled as the normal group.CYFRA21-1,fasting blood glucose(FPG),glycosylated hemoglobin(HbA1c),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),blood albumin(ALB),creatinine(Cr),urinary microalbumin(UAlb)were detected.Information on duration of diabetes were also collected.Results There were significant differences in CYFRA21-1,FPG,HbA1c,TG,HDL-C,blood ALB,UAlb and BMI among the three groups,the difference was statistically significant(P<0.05).CYFRA21-1 was correlated with FPG,HbA1c,LDL-C,HDL-C,ALB,Cr,UAlb,and diabetes duration,the difference was statistically significant(P<0.05).Meanwhile,multinomial regression analysis showed that FPG,HbA1c,HDL-C and LDL-C were the risk factors for the increase of CYFRA21-1,the difference was statistically significant(P<0.05).Conclusion The abnormal increase of serum CYFRA21-1 in T2DM patients is related to many factors.In clinical practice,it should be considered in combination with the levels of blood glucose,HbA1c and blood lipids to avoid misdiagnosis.
作者
陈建栋
陈建中
孟伟
CHEN Jiandong;CHEN Jianzhong;MENG wei(Department of Clinical Laboratory,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《国际检验医学杂志》
CAS
2022年第S01期100-103,共4页
International Journal of Laboratory Medicine
