摘要
近年来,亚甲基水杨酸杆菌肽的抗菌活性被广泛关注,其抗菌谱窄,对许多革兰阳性菌(尤其是产气荚膜梭菌)具有良好的抗菌作用。越来越多的研究表明亚甲基水杨酸杆菌肽治疗畜禽坏死性肠炎具有良好疗效。相对于其他治疗畜禽坏死性肠炎的药物,亚甲基水杨酸杆菌肽具有无残留、不易产生耐药性以及安全系数高等特点。同时,亚甲基水杨酸杆菌肽从动物体内排出的代谢产物能被环境中的微生物分解,对环境不会造成危害。目前,亚甲基水杨酸杆菌肽已被美国FDA批准用于预防和控制鸡、猪、牛等动物梭菌性肠炎。该综述对亚甲基水杨酸杆菌肽的的理化性质、药理作用、安全性以及在畜禽疾病上的应用现状进行总结,为开发其新用途提供参考。
In recent years,the antibacterial activity of bacitracin methylene disalicylate(BMD) has been widely concerned that the antibacterial spectrum has good antibacterial activity against many Gram-positive bacteria.More and more studies had shown that BMD had good results in treating livestock and poultry necrotic enteritis.And with respect to the treatment of other livestock necrotic enteritis,BMD has no residue,not easy to produce resistance and high safety coefficients.At the same time,the metabolite of BMD from the animal could be decomposed by microorganisms in the environment,which was not harmful to the environment.This review focused on the physicochemical properties,pharmacological characteristics and safety of BMD.The application status on livestock and poultry disease was also summarized.
作者
陈珍
杨雨婷
袁礼稳
张雪花
陈冬梅
谢书宇
CHEN Zhen;YANG Yuting;YUAN Liwen;ZHANG Xuehua;CHEN Dongmei;XIE Shuyu(National Veterinary Medicine Residual Reference Laboratory(HZAU),Agricultural Rural Ministry Livestock Product Quality and Safety Risk Assessment Lab(Wuhan),College of Veterinary Medicine,Huazhong Agricultural University,Wuhan Hubei 430070,China)
出处
《中兽医医药杂志》
CAS
2022年第3期36-39,共4页
Journal of Traditional Chinese Veterinary Medicine
基金
中央高校基本科研业务费专项资金(2662020DKPY008)。
关键词
亚甲基水杨酸杆菌肽
有效性
安全性
治疗
坏死性肠炎
bacitracin methylene disalicylate
effectiveness
safety
treatment
necrotic enteritis
