摘要
目的比较早发型(EOPD)和晚发型帕金森病(LOPD)患者非运动症状的特点及差异。方法收集2020年1月至2021年6月在解放军联勤保障部队988医院就诊的原发性PD患者78例,按照发病年龄分为EOPD组(年龄≤50岁,21例)和LOPD组(年龄>50岁,57例);采用Hoehn-Yahr(H-Y)分级量表和国际运动障碍协会帕金森病统一评定量表(MDS-UPDRSⅢ)评估患者的疾病严重程度和运动功能,采用PD自主神经功能量表(SCOPA-AUT)、蒙特利尔认知评估量表(MoCA)、简易智力精神状态量表(MMSE)、帕金森病睡眠量表(PDSS)、汉密尔顿焦虑量表(HAMA)和抑郁量表(HAMD)分别评估自主神经功能、认知功能、睡眠质量、焦虑抑郁状态,比较两组间各症状评分差异。结果EOPD组H-Y分级均明显小于YOPD组(P<0.05),消化道症状、泌尿系统障碍发生率及SCOPA-AUT评分低于LOPD组(P<0.05),MMSE和MOCA评分显著高于LOPD组(P<0.05),睡眠质量评分显著高于LOPD组(P<0.05),焦虑抑郁评分无显著差异(P>0.05)。结论EOPD与LOPD患者在非运动症状中的自主神经功能障碍、认知功能障碍、睡眠障碍方面存在明显差异。
Objective To compare the characteristics and differences of non-motor symptoms in patients with early-onset(EOPD)and late-onset Parkinson's disease(LOPD)patients.Methods 78 PD patients who admitted to 988 Hospital of PLA From January 2020 to June 2021 were enrolled and divided into the EOPD group(≤50 years old,21 cases)and LOPD group(>50 years old,57 cases)according to the onset age.Hoehn-yahr(H-Y)grading scale and Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale-Ⅲ(MDS-UPDRSⅢ)were used to evaluate the disease severity and motor function of patients;Scale of outcomes in PD for autonomic symptom(SCOPA-AUT),Montreal Cognitive Assessment(MoCA),Mini-Mental State Examination(MMSE),Parkinson's Disease Sleep Scale(PDSS),Hamilton Anxiety Scale(HAMA)and Hamilton Depression(HAMD)scales to assess their autonomic nervous function,cognitive function,sleep quality,anxiety and depression.Results Compared with the LOPD group,The H-Y classification of the EOPD group was significantly lower(P<0.05),the incidence of gastrointestinal symptoms,urinary system disorders and SCOPA-AUT scores were lower(P<0.05),the sleep quality scores were significantly higher(P<0.05),and there was no significant difference in the anxiety and depression scores(P>0.05).Conclusion There are obvious differences in autonomic dysfunction,cognitive dysfunction,and sleep disturbance in non-motor symptoms between EOPD and LOPD patients.
作者
张振红
宁群
贺军胜
吕蒙蒙
李志运
张金焱
ZHANG Zhenhong;NING Qun;HE Junsheng;LYU Mengmeng;LI Zhiyun;ZHANG Jinyan(Department of Neurology, the 988th Hospital of the Joint Logistic Support Force, Zhengzhou 450042, China)
出处
《中国老年保健医学》
2022年第2期85-88,共4页
Chinese Journal of Geriatric Care
关键词
早发型帕金森病
晚发型帕金森病
非运动症状
睡眠障碍
Early-onset Parkinson disease
late-onset Parkinson's disease
non-motor symptoms
sleep disorders
comparison
