摘要
目的:探讨2型糖尿病患者并发糖尿病足的影响因素。方法:选取2016年1月-2020年12月在九江市柴桑区人民医院住院的2型糖尿病患者128例,依据是否并发糖尿病足(diabetic food,DF),分为病例组(并发DF)46例和对照组(未并发DF)82例。对糖尿病患者并发糖尿病足进行单因素和多因素分析。结果:病例组与对照组在性别、年龄、糖尿病肾病、糖尿病视网膜病变、收缩压(SBP)、舒张压(DBP)、红细胞(RBC)、血红蛋白(Hb)、尿素氮(BUN)、肌酐(Cr)、尿酸(UA)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、吸烟史、空腹血糖(FBG)方面比较,差异均无统计学意义(P>0.05);病例组与对照组在糖尿病病程、糖尿病周围血管病变、周围神经病变、体重指数(BMI)、白细胞(WBC)、踝肱指数(ABI)、纤维蛋白原(FIB)、血浆D-二聚体(DD)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、血清C肽(FCP)、超敏C反应蛋白(hs-CRP)及Wanger分级方面比较,差异均有统计学意义(P<0.05)。多因素logistic回归分析结果显示,D-D、HbA1c和Wanger分级是2型糖尿病患者并发糖尿病足的独立危险因素,ABI为保护因素(P<0.05)。结论:血浆D-二聚体越高、糖化血红蛋白越高、Wanger分级越严重,则并发糖尿病足的风险越高,ABI为保护因素加强对影响因素的监测,积极采取预防措施,有利于减少糖尿病足的发病率,防治糖尿病足截肢,对于提高患者生活质量具有重要意义。
Objective:To explore the influencing factors of diabetic foot in patients with type 2 diabetes.Method:A total of 128 patients with type 2 diabetes who were hospitalized in Chaisang People’s Hospital of Jiujiang from January 2016 to December 2020 were selected.According to whether diabetic food (DF) was complicated,the patients were divided into case group (concurrent DF) with 46 cases and control group (without concurrent DF) with 82 cases.Univariate and multivariate analyses were performed on diabetic patients with diabetic foot.Result:There were no significant differences in gender,age,diabetic nephropathy,diabetic retinopathy,systolic blood pressure (SBP),diastolic blood pressure (DBP),red blood cells (RBC),hemoglobin (Hb),urea nitrogen (BUN),creatinine (Cr),uric acid (UA),triglyceride (TG),total cholesterol (TC),high density lipoprotein (HDL),smoking history and fasting blood glucose (FBG) between the case group and the control group (P>0.05);there were significant differences in duration of diabetes,diabetic peripheral vascular disease,peripheral neuropathy,body mass index (BMI),white blood cell (WBC),ankle brachial index (ABI),fibrinogen (FIB),plasma D-Dimer (D-D),2 h postprandial blood glucose (2 h PG),glycated hemoglobin (HbA1c),serum C-peptide (FCP),high-sensitivity C-reactive protein (hs-CRP) and Wanger’s classification between the case group and the control group (P<0.05).Multivariate logistic regression analysis showed that D-D,HbA1c,and Wanger classification were independent risk factors for diabetic foot in patients with type 2 diabetes,ABI was a protective factor (P<0.05).Conclusion:The higher the plasma D-Dimer,the higher the glycosylated hemoglobin and the more severe the Wanger classification,the higher the risk of diabetic foot,the ABI is a protective factor,strengthening the monitoring of influencing factors and taking positive preventive measures are beneficial to reduce the incidence rate of diabetic foot and prevent amputation of diabetic foot,which is of great significance to improve the quality of life of patients.
作者
唐俊
杨叔禹
TANG Jun;YANG Shuyu(Chaisang People’s Hospital of Jiujiang,Jiangxi Province,Jiujiang 332100,China;不详)
出处
《中国医学创新》
CAS
2022年第8期120-123,共4页
Medical Innovation of China
基金
国家自然科学基金项目(81673661)。
