摘要
目的探讨子宫动脉栓塞术(UAE)对子宫肌瘤患者激素水平及炎性因子水平的影响。方法选取2018年6月至2020年5月周口市中心医院收治的子宫肌瘤患者78例作为研究对象,按照随机数字表法分成观察组(39例)与对照组(39例),对照组采用腹腔镜子宫肌瘤剔除术,观察组采用UAE治疗,对比两组手术时间、术中出血量及住院时间,分析术前、术后3个月激素水平、炎性因子水平,统计并发症发生情况及复发率。结果与对照组相比,观察组手术时间、住院时间明显更短,差异有统计学意义(P<0.05),术中出血量明显更少,差异有统计学意义(P<0.05);观察组术前、术后3个月促卵泡激素(FSH)、黄体生成素(LH)、雌二醇(E_(2))水平比较,差异无统计学意义(P>0.05),对照组术后3个月FSH、E_(2)水平较术前明显提高,差异有统计学意义(P<0.05),与对照组相比,观察组术后3个月FSH、E_(2)水平更低,差异有统计学意义(P<0.05);两组术后3个月C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)较术前均明显下降,差异有统计学意义(P<0.05),与对照组比较,观察组水平明显更低,差异有统计学意义(P<0.05);观察组术后FSH、E_(2)、CRP、TNF-α异常率明显低于对照组,差异有统计学意义(P<0.05),两组LH异常率比较,差异无统计学意义(P>0.05);观察组并发症发生率明显低于对照组,差异有统计学意义(P<0.05),复发率明显低于对照组,差异有统计学意义(P<0.05)。结论UAE治疗子宫肌瘤患者,手术时间较短,术后恢复快,对激素水平影响较小,可明显降低炎性因子水平,并发症发生少,不易复发。
Objective To investigate the effect of uterine artery embolization(UAE)on the levels of hormones and inflammatory factors in patients with uterine fibroids.Methods A total of 78 patients with uterine fibroids who were admitted in Zhoukou Central Hospital from June 2018 to May 2020 were selected as the research objects,and they were divided into the observation group(39 cases)and the control group(39 cases)according to the random number table method.The control group was treated with laparoscopic myomectomy,and the observation group was treated with UAE.The peration time,intraoperative blood loss and hospital stay of the two groups were compared,and the levels of hormones and inflammatory factors before and 3 months after the operation were analyzed,and the incidence of complications and recurrence rate were calculated.Results Compared with the control group,the operation time and hospital stay in the observation group were significantly shorter(P<0.05),and the intraoperative blood loss was significantly less(P<0.05).There was no significant difference in the levels of folicle(FSH),luteinizing hormone(LH),and estradiol(E_(2))(P>0.05),the levels of FSH and E_(2) in the control group 3 months after surgery were significantly higher than those before surgery(P<0.05),compared with the control group,the levels of FSH and E_(2) in the observation group at 3 months after operation were lower(P<0.05);C reactive protein(CRP)and tumor necrosis factor-α(TNF-α)decreased significantly at 3 months after surgery,and varied significantly(P<0.05),compared with the control group,the levels in the observation group were significantly lower(P<0.05);the abnormal rates of FSH,E_(2),CRP and TNF-αin the observation group after operation were significantly lower than those in the control group(P<0.05).There was no significant difference in the abnormal LH rate between the two groups(P>0.05).The incidence of complications in the observation group was significantly lower than that in the control group(P<0.05),and the recurrence rate was significantly lower than that in the control group(P<0.05).Conclusion UAE in the treatment of uterine fibroids has a shorter operation time,faster postoperative recovery,less impact on hormone levels,and which can significantly reduce the level of inflammatory factors,with fewer complications and less recurrence.
作者
李娇娇
LI Jiaojiao(Department of Obstetrics and Gynecology,Zhoukou Central Hospital,Zhoukou Henan 466000,China)
出处
《临床研究》
2022年第3期76-79,共4页
Clinical Research
关键词
子宫动脉栓塞术
子宫肌瘤
激素水平
炎性因子
uterine artery embolization
uterine fibroids
hormone levels
inflammatory factors
