摘要
目的观察健脾益肺汤辅助治疗儿童哮喘缓解期肺脾气虚证的临床疗效。方法选取2018年7月至2019年7月诸暨市妇幼保健院儿科收治的哮喘缓解期肺脾气虚证患儿120例,采用随机数字表法分为治疗组和对照组,各60例。对照组予布地奈德福莫特罗雾化吸入,治疗组在对照组治疗方法的基础上给予健脾益肺汤治疗,2组均连续治疗3个月后统计疗效。结果对照组总有效率为88.3%(53/60),治疗组为98.3%(59/60),2组比较,差异有统计学意义(P<0.05)。治疗前2组血清白细胞介素-4(IL-4)、干扰素-γ(INF-γ)、核转录因子-κB(NF-κB)、免疫球蛋白E(IgE)、嗜酸性粒细胞(EOS)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组血清NF-κB、IgE、EOS水平均显著降低,INF-γ水平显著升高,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组降低/升高更显著(P<0.05)。治疗前2组呼气流量峰值(PEF)、第1秒用力呼气量(FEV1)、50%肺活量最大呼吸流速(V_(_(max50)))、25%肺活量最大呼吸流速(V_(max25))水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组PEF、FEV_(1)、V_(max50)、V_(max25)水平均明显升高,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组升高更显著(P<0.05)。结论健脾益肺汤辅助治疗小儿哮喘缓解期肺脾气虚证,能明显改善患儿肺功能,提高免疫力,疗效显著,值得临床推广应用。
Objective To observe the clinical efficacy of Jianpi Yifei Tang(健脾益肺汤)in adjuvant treatment of asthma in children with deficiency of lung and spleen qi syndrome in remission stage.Methods From July 2018 to July 2019,120 cases of asthma in children with deficiency of lung and spleen qi syndrome in remission stage admitted into pediatrics department in Zhuji Municipal Maternal and Child Health Hospital were divided into treatment group and control group according to random number table method,with 60 cases in each group.The control group was given aerosol inhalation with budesonide and formoterol fumarate powder for inhalation,on this basis,the treatment group was given Jianpi Yifei Tang.We kept statistics about the efficacy after the 2 groups were both continuously treated for 3 months.Results The total effective rate of the control group was 88.3%(53/60),that of the treatment group was 98.3%(59/60),and the difference was statistically significant between the 2 groups(P<0.05).Before treatment,the difference was not statistically significant in serum levels of interleukin-4(IL-4),interferon-γ(INF-γ),nuclear transcription factor-κB(NF-κB),immunoglobulin E(IgE)and eosinophil(EOS)between the 2 groups(P>0.05),indicating comparability.After treatment,the serum levels of NF-κB,IgE and EOS all significantly decreased,while the levels of INF-γsignificantly increased in the 2 groups,and the difference was statistically significant than those in the same group before treatment(P<0.05),moreover,the decrease/increase in the treatment group was more significant(P<0.05).Before treatment,the difference was not statistically significant in peak expiratory flow(PEF),forced expiratory volume in one second(FEV1),maximal expiratory flow in 50%vital capacity(V_(max50)),maximal expiratory flow in 25%vital capacity(V_(max25))between the 2 groups(P>0.05),indicating comparability.After treatment,the levels of PEF,FEV1,V_(max50) and V_(max25) all significantly increased,and the differences were statistically significant than those in the same group before treatment(P<0.05),moreover,the treatment increased more significantly(P<0.05).Conclusion It can markedly improve the lung function and immunity to use Jianpi Yifei Tang in adjuvant treatment of asthma in children with lung spleen qi deficiency syndrome in remission stage with marked curative efficacy,which is worthy of clinical promotion and application.
作者
王金范
王其莉
毛立英
WANG Jinfan;WANG Qili;MAO Liying(Department of Pediatrics,Zhuji Municipal Maternal and Child Health Hospital,Zhuji,Zhejiang,311800,China;Department of Pediatrics,The First Hospital Affiliated to Zhejiang Chinese Medical University,Hangzhou,Zhejiang,310000,China)
出处
《中医儿科杂志》
2022年第2期53-56,共4页
Journal of Pediatrics of Traditional Chinese Medicine
关键词
小儿哮喘
缓解期
肺脾气虚证
健脾益肺汤
临床观察
asthma in children
remission stage
lung spleen qi deficiency syndrome
Jianpi Yifei Tang(健脾益肺汤)
clinical observation
