摘要
随着L-色氨酸市场需求增大,L-色氨酸生物合成调控逐渐成为研究热点。该文综述了L-色氨酸的应用范围、生产方式及生物合成代谢调控策略。从L-色氨酸的系统代谢网络出发,综述了L-色氨酸在中心代谢途径、莽草酸途径以及分支酸途径中的遗传调控策略,主要包含了增加胞内前体物、阻断分支酸途径、削弱负调控和改造转运系统等。
With the increasing market demand for L-tryptophan,the regulation of L-tryptophan biosynthesis had gradually become a research hotspot.The application range,production mode and biosynthesis and metabolism regulation strategy of L-tryptophan were summarized in this paper.Based on the systematic metabolic network of L-tryptophan,this manuscript reviews the genetic regulation strategies of L-tryptophan in central metabolic pathway,shikimate pathway and branching pathway,including increasing intracellular precursors,blocking branching pathway,weakening the negative regulation and modifying transport system,and so on.
作者
臧珊珊
林涛
郭兴
李芹
张怀东
刘峰
ZANG Shan-shan;LIN Tao;GUO Xing;LI Qin;ZHANG Huai-dong;LIU Feng(College of Life Science,Fujian Normal University,Fuzhou 350117;Collaborative Innovation Center of Haixi Green Biological Manufacturing Technology,Fuzhou 350117;Engineering Research Center for Industrial Microbiology,Ministry of Education,Fuzhou 350117,China)
出处
《生物技术》
CAS
2022年第1期99-106,84,共9页
Biotechnology
基金
福建省自然科学基金面上项目(2018J01724)。
