摘要
目的探讨急性脑梗死患者同型半胱氨酸、纤维蛋白原水平及中性粒细胞/淋巴细胞比值与颈内动脉狭窄程度及近期预后的关系。方法将261例急性脑梗死患者按头颈部CT血管造影结果分为狭窄组(93例)与无狭窄组(168例),比较两组一般资料及同型半胱氨酸、纤维蛋白原水平及中性粒细胞/淋巴细胞比值。比较狭窄组颈内动脉不同狭窄程度、不同预后患者同型半胱氨酸、纤维蛋白原水平及中性粒细胞/淋巴细胞比值,并采用Spearman相关分析探讨上述指标与颈内动脉狭窄程度及预后(改良Rankin量表评分)的相关性。结果本组患者中颈内动脉狭窄93例(35.6%),无狭窄168例(64.4%)。狭窄组同型半胱氨酸、纤维蛋白原水平及中性粒细胞/淋巴细胞比值均显著高于无狭窄组(P<0.05)。随着颈内动脉狭窄程度的加重,患者同型半胱氨酸、纤维蛋白原水平及中性粒细胞/淋巴细胞比值升高,差异有统计学意义(P<0.05)。预后不良患者同型半胱氨酸、纤维蛋白原水平及中性粒细胞/淋巴细胞比值显著高于预后良好患者(P<0.05)。同型半胱氨酸、纤维蛋白原水平及中性粒细胞/淋巴细胞比值与颈内动脉狭窄率、改良Rankin量表评分呈显著正相关(P<0.05)。结论急性脑梗死患者同型半胱氨酸、纤维蛋白原水平及中性粒细胞/淋巴细胞比值明显升高,且与颈内动脉狭窄程度、预后关系密切,可作为颈内动脉狭窄程度及预后的预测评估指标。
Objective To explore the correlation between homocysteine(Hcy),fibrinogen(FIB),neutrophil-to-lymphocyte ratio(NLR)and internal carotid artery stenosis,prognosis of patients with acute cerebral infarction(ACI).Methods A total of 261 ACI patients were divided into stenosis group(93 cases)and non-stenosis group(168 cases)according to the CT angiography results of head and neck.The clinical data,levels of Hcy,FIB and NLR were compared between the two groups.The levels of Hcy,FIB and NLR in patients with different degrees of internal carotid artery stenosis and different prognosis were compared in the stenosis group.And Spearman correlation analysis was used to explore the correlation between the above indicators and the degree of internal carotid artery stenosis and prognosis(modified Rankin scale score).Results In this group,93 cases(35.6%)had internal carotid artery stenosis and 168 cases(64.4%)had no stenosis.The levels of Hcy,FIB and NLR in stenosis group were significantly higher than those in non-stenosis group(P<0.05).With the aggravation of internal carotid artery stenosis,the levels of Hcy,FIB and NLR increased,and the differences were statistically significant(P<0.05).Hcy,FIB and NLR in patients with poor prognosis were significantly higher than those in patients with good prognosis(P<0.05).Hcy,FIB and NLR were significantly positively correlated with internal carotid artery stenosis rate and modified Rankin scale(mRS)score(P<0.05).Conclusions Hcy,FIB and NLR in ACI patients increased significantly,which were closely related to the degree of internal carotid artery stenosis and prognosis.They can be applied as auxiliary indexes of internal carotid artery stenosis and prognosis.
作者
陈艳芳
贾贺
李富慧
黄景贺
Chen Yanfang;Jia He;Li Fuhui;Huang Jinghe(First author's address Nanyang Central Hospital,Nanyang 473000,Henan,China)
出处
《临床心身疾病杂志》
CAS
2022年第2期6-10,共5页
Journal of Clinical Psychosomatic Diseases
基金
河南省医学科技攻关计划项目(编号182102310184)。
